Luciferase expression in AdPyCS-immunized mice, AdPyCelTOS-immunized mice, or naïve mice, upon HTV injection of DNAPyCelTOS-Luc. (a) Noninvasive bioluminescence image shows the inhibition of DNAPyCelTOS-Luc induced luciferase expression in mice by a prior single immunizing dose of AdPyCelTOS, but not of AdPyCS. Three days after the HTV injection with DNAPyCelTOS-Luc, mice were anesthetized and injected with D-luciferin, and the luciferase intensity was optically imaged; (b) Quantificationof the bioluminescent signal intensity in AdPyCS-immunized mice, AdPyCelTOS-immunized mice, or naïve mice, upon HTV injection of DNAPyCelTOS-Luc.