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. 2014 May 27;9(5):e99148. doi: 10.1371/journal.pone.0099148

Correction: Ultra High-Resolution Gene Centric Genomic Structural Analysis of a Non-Syndromic Congenital Heart Defect, Tetralogy of Fallot

The PLOS ONE Staff
PMCID: PMC4035336

Table 2 is missing in the XML and PDF versions of the article. Please see Table 2 below.

Table 2. CNVs containing genes with a known association with right ventricular development1 .

Chromosome Gene Band Start2 Stop2 Size2 # in TOF cohort / total in cohort inheritance Mills et al 20063 # with CNV / total in cohort Jiang et al 20133 # With CNV / total in cohort DGV # With CNV/ total in cohort
chr20 JAG1 p12.2 10,653,282 10,654,729 1,447 1del/34 from mother 0 / 24 2 /32
chr17 TBX2 q23.2 59,477,025 59,479,140 2,115 3dup,1del/34 3 denovo / 1 dup from father 0 / 24 3/ 32
chr18 GATA6 q11.2 19,749,386 19,761,617 12,231 2del/34 1 denovo / 1 from mother 0 / 24 9 / 32
chr9 NOTCH1, q33.3 - q34.3 130,158,557 140,785,695 10,267,138 2del/34 1 denovo / 1 from mother 10 / 24 7 / 32
chr8 HEY1 q21.33 8,0679,052 80,727,908 48,856 3dup, 4del/34 0 /24* 0 /32**
chr1 RYR2 q43 237,813,301 237,817,763 4,462 2del/34 2/24 13 /32
chr8 FOXH1 q24.3 142,286,322 145,755,059 3,468,737 2del/34 0 /24 1 /32
chr1 NOTCH2 p12 - p11.2 120,529,652 120,612,294 82,642 2del/34 1 / 24 0 / 32
chr16 SOX8 p13.3 126,558 3,790,511 3,663,953 2del/34 2 / 24 4/ 32
chr3 DVL3 q27.1 183,872,674 184,242,147 369,473 2del/34 0 / 24 4/32
chr6 SOX4 p22.3 21,594,198 21,596,935 2,737 1del/34 0 / 24 1/32
chr7 LFNG p22.3 165,353 2,706,165 2,540,812 1del/34 0 / 24 9/ 32
chr8 CHD7 q12.1 61,582,823 61,591,393 8570 1dup,2del/34 0 / 24 2/32
chr14 NKX2.14 q13.3 36,986,373 36,991,296 4,923 12/34 all deletions 0 / 24*** 2 / 32*** 2/450***
chr3 CHL14 p26.3 115,283 305,668 190,385 19/34 all deletions 1 / 24*** 2/32*** 1/30[37]*** and 2/450[38]***
chr22 GSTT14 q11.23 24,236,629 24,384,403 147,774 3 del,22 dup/34 0 / 24*** 2/ 32*** 21/30[37] and 630/1184[39]***
1

the genes were identified using the GO terms right ventricle morphogenesis or outflow track morphogenesis

2

If there is more than one CNV, start, stop and size represent the largest CNV

3

Mills et al. [30] and Jiang et al.[31] datasets were downloaded and searched for small CNVs (> 100 bp to 10kb) anywhere in the gene or in the 10kb upstream or downstream to include the promoter and 3’ end.

4

NKX2.1, CHL1 and GSTT1 do not have a direct connection to RV development but were included because of the high frequency of CNVs involving them in our cohort

*, **, ***significant difference p<0.05, 0.01, 0.001

Reference


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