Table 1.
Potential urine biomarkers of bladder cancer (1-12) and mRNA expression of related genes in BCs relative to control tissue (13-15)a.
| NO. | m/z | Adduct | Metabolite/gene | Element composition/symbol | p-valueb | Trendc |
| 1 | 119.0362 | [M+H]+ | Succinate | C4H6O4 | 2.0E-02 | ↑ |
| 2 | 130.0491 | [M+ACN+H]+ | Pyruvated | C3H4O3 | 1.2E-02 | ↑ |
| 3 | 147.0285 | [M+H]+ | Oxoglutarated | C5H6O5 | 5.9E-03 | ↑ |
| 4 | 162.1109 | [M+H]+ | Carnitine | C7H15NO3 | 5.1E-03 | ↑ |
| 5 | 169.0083 | [M+H]+ | Phosphoenolpyruvate | C3H5O6P | 1.1E-02 | ↑ |
| 6 | 189.1602 | [M+H]+ | Trimethyllysine | C9H20N2O2 | 3.1E-03 | ↑ |
| 7 | 233.1104 | [M+H]+ | Melatonin | C13H16N2O2 | 6.7E-04 | ↓ |
| 8 | 246.1695 | [M+H]+ | Isovalerylcarnitine | C12H23NO4 | 6.0E-04 | ↑ |
| 9 | 276.1441 | [M+H]+ | Glutarylcarnitine | C12H21NO6 | 2.2E-09 | ↓ |
| 10 | 286.2010 | [M+H]+ | Octenoylcarnitine | C15H27NO4 | 2.4E-04 | ↑ |
| 11 | 316.2465 | [M+H]+ | Decanoylcarnitine | C17H33NO4 | 7.9E-05 | ↓ |
| 12 | 810.1328 | [M+H]+ | Acetyl-CoA | C23H38N7O17P3S | 4.1E-02 | ↑ |
| 13 | - | Carnitine palmitoyltransferase | CPT1A | 8.4E-03 | ↑ | |
| 14 | - | Carnitine acylcarnitine translocase-like protein (CACL) | SLC25A29 | 3.9E-03 | ↑ | |
| 15 | - | Dihydrolipoyl dehydrogenase (Pyruvate dehydrogenase complex) | DLD | 1.0E-07 | ↓ |
aThe mRNA expression levels are from our microarray experiment, which was reported previously 23.
" id="tabb">b The p-values are from Student's t-tests.
" id="tabc">c The trend of the marker levels in the BC group. ↑ and ↓ indicate increased and decreased levels, respectively in the cancer group.
" id="tabd">d Tentative identification.