Table 2.

In vitro results for derivatives of the parent scaffold, 2.

Compound	Ki (uM)	LE[a]	LiPE[b]
2	9.0 ± 2.0	0.53	5.3
4	2.5 ± 0.4	0.45	6.0
15	21 ± 5.0	0.46	4.4
18	12 ± 3.6	0.30	5.0
24	830 ± 75	0.20	1.9
26	13 ± 2.4	0.48	4.5
29	6.4 ± 3.5	0.34	6.6

^[a]Ligand efficiencies (LE) determined by converting K_i values to binding energies and dividing by the number of non-hydrogen atoms. Units = kcal/mol/atom.

^[b]Lipophilic efficiences (LiPE) determined by subtracting logP values from the log(K_i) for each compound.