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Measurement of glucagon levels in the blood of RenCre x p53/Rb animals and Cre – littermates. At 2 months of age the RenCre x p53/Rb animals have normal circulating glucagon levels in their blood stream when compared to normal Cre− age-matched littermates. Dramatic increase in 4,5, and 6 month time-points of glucagon levels, characteristic of a glucagonoma.
