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. Author manuscript; available in PMC: 2015 Jul 7.
Published in final edited form as: Analyst. 2014 Jul 7;139(13):3274–3280. doi: 10.1039/c3an02324a

Figure 4.

Figure 4

Drug response of suspended B lymphocyte cancer cells. Ramos B cells were treated with 2 μM staurosporine at normoxic (purple triangles) and hypoxic (red circles) conditions. Control measurements were performed (black squares) for 6 hours under normoxic conditions without staurosporine. The number of cells with depolarized mitochondria were measured as a function of time. The response of B cells toward staurosporine was not significantly different under hypoxic and normoxic conditions. Suspended cells do not posses hypoxic regions. Therefore, hypoxia adaptive mechanism is not present in these kinds of cells rendering them susceptible to drugs even at hypoxic conditions.