The footnotes are missing from Table 2. Please see the complete, corrected Table 2 here.
Table 2. Cardiac morphology and function in sham-operated and TAC WT and VEETKO mice twelve weeks after operation, receiving PTX or not.
| Sham-operated mice | TAC mice | |||||||
| control | PTX treated | control | PTX treated | |||||
| WT | VEETKO | WT | VEETKO | WT | VEETKO | WT | VEETKO | |
| n | 5 | 7 | 5 | 8 | 5 | 9 | 6 | 9 |
| Body weight (g) | 25,3±2,3 | 28,5±2,1 | 24,7±0,8 | 29,4±1,6 | 26,1±2,4 | 27,4±1,3 | 26,7±2,3 | 26,3±1,2 |
| Heart weight / body weight (mg/g) | 0,43±0,03 | 0,43±0,01 | 0,43±0,01 | 0,41±0,01 | 0,54±0,03* | 0,60±0,04* | 0,55±0,02* | 0,50±0,01*,‡ |
| Heart weight / tibia length (mg/mm) | 0,62±0,04 | 0,65±0,06 | 0,58±0,03 | 0,61±0,01 | 0,85±0,08* | 0,86±0,07* | 0,77±0,03* | 0,73±0,04* |
| Cardiomyocytes diameter (ìm) | 13,5±0,4 | 13,5±0,8 | 13,0±0,6 | 13,5±0,2 | 15,7±1,1 | 16,5±0,5* | 15,2±1,0 | 14,6±0,8 |
| Heart rate (bpm) | 624±14 | 657±10 | 657±15 | 646±23 | 643±3 | 648±12 | 688±22 | 662±13 |
| Systolic blood pressure (mmHg) | 108±3 | 112±2 | 122±2|| | 113±2 | 113±6 | 104±3 | 111±5 | 106±3 |
| Left ventricular end systolic dimension (mm) | 1,33±0,20 | 1,25±0,17 | 1,33±0,19 | 1,44±0,15 | 1,19±0,15 | 1,63±0,09*,† | 1,56±0,17 | 1,19±0,13‡ |
| Left ventricular end diastolic dimension (mm) | 2,93±0,08 | 2,67±0,21 | 2,87±0,11 | 2,91±0,19 | 2,73±0,26 | 3,14±0,11* | 2,97±0,20 | 2,52±0,20‡ |
| Fractional shortening (%) | 52,7±4,7 | 54,6±2,9 | 51,2±3,2 | 50,5±3,1 | 56,8±2,4 | 48,4±1,6*,† | 46,1±1,3† | 53,1±3,2‡,§ |
Table 2: Cardiac morphology and function in sham-operated and TAC WT and VEETKO mice twelve weeks after operation, receiving PTX or not. * p<0.05 vs. sham-operated same genotype, † p<0.05 vs. control TAC-WT, ‡p<0.05 vs. control TAC-VEETKO, § p<0.05 vs. PTX TAC-WT, || p<0.05 vs. control sham-operated WT. (WT: wild type, VEETKO: vascular endithelial endothelin-1 knock-out, TAC: transaortic constriction, PTX: pentoxifylline).
Reference
- 1. Heiden S, Vignon-Zellweger N, Masuda S, Yagi K, Nakayama K, et al. (2014) Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice. PLoS ONE 9(2): e88730 doi:10.1371/journal.pone.0088730 [DOI] [PMC free article] [PubMed] [Google Scholar]
