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. 2014 Jun 4;9(6):e99473. doi: 10.1371/journal.pone.0099473

Correction: Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice

The PLOS ONE Staff
PMCID: PMC4045968

The footnotes are missing from Table 2. Please see the complete, corrected Table 2 here.

Table 2. Cardiac morphology and function in sham-operated and TAC WT and VEETKO mice twelve weeks after operation, receiving PTX or not.

Sham-operated mice TAC mice
control PTX treated control PTX treated
WT VEETKO WT VEETKO WT VEETKO WT VEETKO
n 5 7 5 8 5 9 6 9
Body weight (g) 25,3±2,3 28,5±2,1 24,7±0,8 29,4±1,6 26,1±2,4 27,4±1,3 26,7±2,3 26,3±1,2
Heart weight / body weight (mg/g) 0,43±0,03 0,43±0,01 0,43±0,01 0,41±0,01 0,54±0,03* 0,60±0,04* 0,55±0,02* 0,50±0,01*,‡
Heart weight / tibia length (mg/mm) 0,62±0,04 0,65±0,06 0,58±0,03 0,61±0,01 0,85±0,08* 0,86±0,07* 0,77±0,03* 0,73±0,04*
Cardiomyocytes diameter (ìm) 13,5±0,4 13,5±0,8 13,0±0,6 13,5±0,2 15,7±1,1 16,5±0,5* 15,2±1,0 14,6±0,8
Heart rate (bpm) 624±14 657±10 657±15 646±23 643±3 648±12 688±22 662±13
Systolic blood pressure (mmHg) 108±3 112±2 122±2|| 113±2 113±6 104±3 111±5 106±3
Left ventricular end systolic dimension (mm) 1,33±0,20 1,25±0,17 1,33±0,19 1,44±0,15 1,19±0,15 1,63±0,09*,† 1,56±0,17 1,19±0,13‡
Left ventricular end diastolic dimension (mm) 2,93±0,08 2,67±0,21 2,87±0,11 2,91±0,19 2,73±0,26 3,14±0,11* 2,97±0,20 2,52±0,20‡
Fractional shortening (%) 52,7±4,7 54,6±2,9 51,2±3,2 50,5±3,1 56,8±2,4 48,4±1,6*,† 46,1±1,3† 53,1±3,2‡,§

Table 2: Cardiac morphology and function in sham-operated and TAC WT and VEETKO mice twelve weeks after operation, receiving PTX or not. * p<0.05 vs. sham-operated same genotype, † p<0.05 vs. control TAC-WT, ‡p<0.05 vs. control TAC-VEETKO, § p<0.05 vs. PTX TAC-WT, || p<0.05 vs. control sham-operated WT. (WT: wild type, VEETKO: vascular endithelial endothelin-1 knock-out, TAC: transaortic constriction, PTX: pentoxifylline).

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