Table 3.

Regression estimated average incremental monthly costs by adverse event count ^‡

	1st Line Taxane	1st Line Capecitabine	2nd Line Taxane	2nd Line Capecitabine
With any adverse event, $
Chemotherapy costs	$478**	$630*	$513**	$118
Other medication costs	-$5	$176*	-$54*	$139*
Hospitalization costs	$920**	$1,745*	$441**	$2,771*
Emergency department costs	$29	$43*	$17	$91*
Outpatient services costs	-$280**	-$777*	$531*	$1,319
Total costs	$1,142**	$1,817*	$1,448**	$4,437*
With 1–2 adverse events, $
Chemotherapy costs	$342*	$75	$22	$1
Other medication costs	-$3	$151*	-$13	$52
Hospitalization costs	$169	$755	$57	$1,018
Emergency department costs	-$6	$25	$23	$34
Outpatient services costs	-$226*	-$903*	$154	-$19
Total costs	$276	$104	$243	$1,087
With 3–4 adverse events, $
Chemotherapy costs	$549*	$551	$325*	-$283
Other medication costs	$14	$220*	-$101*	$260*
Hospitalization costs	$296	$1,648	$183	$1,221
Emergency department costs	-$12	$50	-$3	$174*
Outpatient services costs	-$182	-$817	$1,103**	$693
Total costs	$667*	$1,652	$1,506**	$2,065
With greater than 4 adverse events, $
Chemotherapy costs	$488*	$1,537**	$1,053**	$535
Other medication costs	-$17	$192*	-$71*	$191*
Hospitalization costs	$1,389**	$3,393**	$934**	$5,777**
Emergency department costs	$54*	$67*	$24	$128*
Outpatient services costs	-$353**	-$555	$593*	$3,323*
Total costs	$1,562**	$4,635**	$2,533**	$9,954**

^‡Relative to those with no adverse events and adjusted for age (linear) and Charlson Comorbidity Index (categorized 0, 1, 2, and 3+), *p < 0.05, **p < 0.0001.