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. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: Nature. 2014 Feb 19;506(7489):451–455. doi: 10.1038/nature13109

Extended Data Figure 2. Comparison of genomic aberrations among ependymomas analysed by Whole Genome Sequencing.

Extended Data Figure 2

(a) The great majority of ependymomas have <10 coding SNV. Samples with >20 coding SNVs and their corresponding sample number from Fig. 1 are shown. (b) Comparison of total number of SVs in PF and ST samples (Wilcox rank sum, p=0.0006). (c) CIRCOS plot depicting SVs discovered across all supratentorial (red, outer plot) and posterior fossa (blue, inner plot) ependymomas. Each dot represents a validated or putative SV breakpoint detected by CREST in the WGS discovery cohort. Note the highly focal clustering of SVs on Chr11q in supratentorial ependymomas.