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. Author manuscript; available in PMC: 2014 Oct 3.
Published in final edited form as: Nature. 2014 Apr 3;508(7494):113–117. doi: 10.1038/nature13187

Figure 3. Lineage-restricted subclones recapitulate mosaiform heterogeneity in chimeric cWnt/iWnt tumors.

Figure 3

a, Schematic. b, DNA sequence chromatograms depicting matching HRasGGA12AGA mutations detected in unsorted and sorted populations from primary and relapsed tumors as indicated. c, Immunostaining of basal (SMA, top panels) and luminal (Keratin-8, lower panels) tumor cells within a Dox-independent relapse arising on a cWnt host. Red fluorescence marks donor-derived iWnt/mRFP+ cells intermingled with mRFP− host-derived cells. Scale bar, 50μm.