Table 2. Rates of psychiatric disease in manifesting carriers and tremor cohorts.
| Lifetime disorder DSM-IV | MC n (%) (total = 27) | Tremor n (%) (total = 45) | Population estimates (%) |
|---|---|---|---|
| Any DSM-IV disorder | 21 (77.8) | 28 (62.2) | 48a |
| Major depressive disorder | 12 (44.4) | 20 (44.4) | 17.1a |
| Mania and hypomania | 0 (0) | 3 (6.7) | 1.6a |
| Panic disorder | 9 (33.3) | 17 (37.8) | 3.5a |
| Agoraphobia | 6 (22.2) | 7 (15.6) | 5.3a |
| Social phobia | 12 (44.4) | 8 (17.8) | 13.3a |
| OCD—overall | 16 (59.2) | 8 (17.8) | 4b |
| Obsessions | 4 (14.8) | 8 (17.8) | |
| Compulsions | 14 (51.9) | 6 (13.3) | |
| Alcohol dependence/abuse | 8 (29.6) | 6 (13.3) | 14.1a |
| Psychotic and mood disorders | 1 (3.7) | 9 (20) | 0.7a |
| Generalized anxiety disorder | 13 (48.1) | 3 (6.7) | 5.1a |
a
Values taken from National Comorbidity Survey (Kessler et al., 1994).
b
Values from Dunedin Longitudinal Birth Cohort Study (Douglass et al., 1995).
MC = manifesting carrier; NMC = non-manifesting carrier; NC = non-carrier.