Fig. 3.

Example of diffusion tensor imaging (DTI)-based versus constrained spherical deconvolution (CSD)-based tractography in the rat corpus callosum.⁴³ DTI (B) is the most commonly used tractography method despite well-documented limitations that result in the underestimation of tracts.⁴⁰ Advances in higher-order tractography models, such as CSD (C), provide more sensitive and accurate representations of white matter tracts, and might be applied in future studies investigating brain connectivity in epileptogenesis.