Prolonged acute migraine with aura and reversible brain MRI abnormalities after liquid sclerotherapy

Abstract

Transient visual disturbances constitute the most commonly reported neurological side effect during and immediately after sclerotherapy. A few studies, based on clinical and diffusion-weighted MRI assessments, have suggested that these transient neurological symptoms correspond to migraine with aura. Recently, it has been reported that brain magnetic resonance imaging can reveal transient T2*-weighted abnormalities during the acute phase of migraine with aura. We reported a 36-year-old man who presented with transient neurological symptoms and concomitant T2*-weighted abnormalities on brain magnetic resonance imaging immediately after liquid sclerotherapy. We hypothesize that the reversible nature of the patient’s T2*-weighted abnormalities may indicate a relationship with the post-sclerotherapy migraine with aura attack.

Background

Transient visual disturbances constitute the most commonly reported neurological side effect during and immediately after sclerotherapy, with an incidence of 1.4%s [1]. Furthermore, foam sclerotherapy appears to be associated with a higher incidence of transient visual disturbances than liquid sclerotherapy [2]. Research has suggested that these transient neurological symptoms (which are more frequent in patients with patent foramen ovale (PFO) and/or a history of migraine) correspond to migraine with aura (MA) [3-5].

More recently, it has been reported that brain magnetic resonance imaging (MRI) can reveal transient T2*-weighted abnormalities during the acute phase of MA [6-8].

Here, we report on a patient who presented with transient neurological symptoms and concomitant T2*-weighted abnormalities on MRI immediately after liquid sclerotherapy. We hypothesize that the reversible nature of the patient’s T2*-weighted abnormalities may indicate a relationship with the post-sclerotherapy MA attack.

Case presentation

A 36-year-old man presented with symptomatic but moderate varicosity of the left small saphenous vein. The patient had no vascular risk factors, no history of venous diseases, no family history of migraine and no reported migraine comorbidities. He reported a few episodes of headache, the description of which was compatible with migraine without aura. In February 2014, he underwent liquid sclerotherapy (carried out in accordance with the European consensus statement) [9]. After contraindications to treatment were ruled out and the patient had given his written, informed consent, the first sclerotherapy session (with a total of 2 ml of 0.25% lauromacrogol solution) was not followed by any complications. Two weeks later, the patient received a second injection of 4 ml of 0.25% lauromacrogol solution. Immediately following the injection, the patient reported flickering lights in his right eye and several minutes of photopsiae, followed by right hemianopsia. These symptoms disappeared after two hours. Two weeks later, the patient underwent a third sclerotherapy (with 4 ml of 0.25% lauromacrogol solution). Immediately following injection of the liquid, the patient again reported flickering lights in his right eye, followed by right hemianopsia and (two hours later) the progressive onset of aphasia and psychomotor slowing. Comprehension was not affected. An evaluation by a neurologist revealed headache, right hemianopia, mild word-finding difficulties and a slowly progressing disturbance of consciousness. The National Institutes of Health Stroke Scale (NIHSS) score was 4 out of 42 [10]. Brain MRI (performed three hours after symptom onset) was normal. However, gradient-echo T2*-weighted images revealed several hypointense areas in both hemispheres of the brain (though predominantly in the left hemisphere) (Figure 1A). The patient’s movement prevented us from interpreting the results of magnetic resonance angiography of the Circle of Willis. Since the acute symptoms persisted, acute encephalopathy was suspected. Although the results of a cerebrospinal fluid analysis were normal, treatment with acyclovir was initiated. The chest radiography was unremarkable. The electrocardiogram, carotid ultrasonography, transcranial Doppler ultrasound and transthoracic echocardiography results were normal. The laboratory test results (including thyroid function, arterial blood gas measurement, and syphilis screening tests) were also normal. The coagulation work-up did not show any factor V Leiden or prothrombin gene G20210A mutations, and protein C, protein S, antithrombin III, factor VIII and homocysteine levels were normal. Antibody screening was negative. Transoesophageal echocardiography revealed a PFO with an associated atrial septal aneurysm. A color flow duplex scan revealed a moderate right-to-left shunt but only during provocation tests. The cardiac valves were normal, and there was no evidence of aortic atheroma or pulmonary arterial hypertension. The colour duplex ultrasonography results for the lower limbs were normal. After 48 h, the symptoms (including the headache) resolved spontaneously and the patient was diagnosed with probable migraine with aura (on the basis of this first episode of migraine with prolonged aura). Brain MRI was repeated five days after symptom onset and the T2* images were normal (Figure 1B). The patient was discharged six days after admission, with a favourable outcome (NIHSS score: 0). Following hospitalisation, the patient suffered from to other episodes of migraine with aura lasting for less than 1 hour.

Figure 1.

A gradient-echo T2*-weighted magnetic resonance image showing hypointense signals in both hemispheres of the brain but especially in the left hemisphere (A) and a normal gradient-echo T2*-weighted magnetic resonance image acquired five days after the migraine attack (B).

Conclusions

In migraine with aura, visual disturbances may comprise additional features (such as flickering lights and spots), or the loss of features (such as hemianopia and loss of vision) and may be associated with sensory disturbance and speech impairment (depending on the extent of cortical spreading depression (CSD) [1,11]. These complications appear to be more frequent after foam sclerotherapy than after liquid sclerotherapy [2]. Although the degree to which the injected volume of sclerotic agent contributes to the development of neurological side effects is subject to debate, it appears reasonable to decrease the volume when (i) neurological symptoms occurs after sclerotherapy and (ii) another sclerotherapy session is required [11]. Recent clinical and brain MRI studies have shown that these transient neurological symptoms (which are more frequent in patients with PFO) correspond to MA rather than to transient ischemic events [5,12].

Migraine with aura occurs in about one third of migraine sufferers [13]. It is clinically defined by at least two recurrent episodes of fully reversible symptoms (the most frequent of which are visual disturbances, sensory disturbances and speech and/or language impairment). The aura symptom spreads gradually over a period of 5 minutes and (for each individual aura) lasts between 5 and 60 minutes (although this upper limit was set arbitrarily). Indeed, it has been reported that aura lasts for more than one hour in up to 37% of patients [14]. This epidemiological reality has been recently taken into consideration in the third edition of the International Classification of Headache Disorders, in which aura lasting more than an hour but less than a week (in the absence of radiologically confirmed brain ischemia) was defined as “probable migraine with aura (prolonged aura)” [15]. These atypical clinical presentations always warrant a thorough work-up, since cerebrovascular disease must be always considered [16]. As such, brain MRI is usually required to carefully screen for the underlying cause during the acute phase. Recently, transient T2*-weighted imaging abnormalities on brain MRI have been reported during the acute phase of MA [6-8]. The occurrence of these transient T2*-weighted imaging abnormalities after sclerotherapy lends support to the hypothesis whereby endothelin release and microembolization trigger CSD [17]. The two most likely explanations for these T2* findings relate to (i) increased oxygen consumption and a subsequent increase in the intravenous deoxyhaemoglobin concentration [18] and (ii) venous dilatation following the release of vasoactive factors (such as endothelin). In murine models, systemic levels of endothelin-1 (ET-1, one of the most potent vasoconstrictors and a CSD inducer) are significantly elevated one and five minutes after the initiation of foam sclerothapy [19]. Furthermore, Lemos et al.'s study of a population of Portuguese patients revealed a possible role for the endothelin receptor type A in migraine without aura [20]. Nevertheless, the prevalence and significance of these phenomena merit further investigation.

In conclusion, the present observation suggests that the transient nature of the T2*-weighted imaging abnormalities is associated with a CSD caused by migraine aura after sclerotherapy.

Consent

Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this Journal.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YZ conceived the study, participated in its design and coordination and helped to draft the manuscript. MT has made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data. MH has made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data. DS participated in the design of the study, and helped to draft the manuscript. JMC has made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data. JMB conceived the study, participated in its design and coordination, helped to draft the manuscript, and has been involved in revising it for important intellectual content. All the authors have participated sufficiently in the work to take public responsibility for appropriate portions of the content. All authors read and approved the final manuscript.

Acknowledgments

We thank David Fraser PhD for providing medical writing services on behalf of Amiens University Hospital.