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. Author manuscript; available in PMC: 2015 Jun 17.
Published in final edited form as: Vaccine. 2014 May 6;32(29):3573–3576. doi: 10.1016/j.vaccine.2014.04.086

Figure 2. HKY vaccine significantly reduced lung fungal burden in DKA/cortisone acetate-treated mice infected with R. oryzae.

Figure 2

Mice were vaccinated with 3 doses of 6.0 × 107 of HKY. Control mice were given PBS alone. Mice were then treated to produce DKA and treated with cortisone acetate prior to intratracheal infection with R. oryzae 99-880 isolate at 2.5 × 105 spores (delivered inoculum = 2.0 × 103 spores per mouse). Mice (n=10 per arm) were euthanatized at day 3 postinfection for determination of fungal burden in lungs and brains by quantitative PCR. *P <0.05 vs. Control by Wilcoxon Rank Sum test.