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. 2014 Jan 1;24(1):397. doi: 10.1016/j.bmcl.2013.11.012

Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues” [Bioorg. Med. Chem. Lett. 23 (2013) 6019–6024]

Jonathan M Large a,, Simon A Osborne a, Ela Smiljanic-Hurley a, Keith H Ansell a, Hayley M Jones a, Debra L Taylor a, Barbara Clough b, Judith L Green b, Anthony A Holder b
PMCID: PMC4074339

Table 4 appeared incorrectly. The corrected table appears below.

Table 4.

Selected cyanophenyl pyrazoles

Compound R1-X R2 PfCDPK1 IC50 (μM) Pf EC50a (μM) m Log D HLM % remb MLM % remb
29 graphic file with name fx2.gif graphic file with name fx3.gif 0.056 0.262 1.9 80 84
36 graphic file with name fx4.gif graphic file with name fx5.gif 0.854 nt 1.9 79 59
37 graphic file with name fx6.gif graphic file with name fx7.gif 0.189 0.255 2.7 70 59
38 graphic file with name fx8.gif graphic file with name fx9.gif 0.070 0.103 1.2 93 90
a

nt = not tested.

b

% remaining after 30 min.

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