Table 1.
Linker structures and % yield (for two steps) for the synthesis of dimeric neomycins.
| Neomycin dimer | Linker length | Structure of the linker (-x-, from Scheme 1 and Scheme 2) | % yield |
|---|---|---|---|
| DPA51 | 7 |
|
89.5 |
| DPA52 | 7 |
|
88.2 |
| DPA65 | 7 |
|
83.0 |
| DPA53 | 8 |
|
87.0 |
| DPA54 | 8 |
|
88.5 |
| DPA55 | 10 |
|
82.0 |
| DPA56 | 10 |
|
88.8 |
| DPA58 | 16 |
|
83.5 |
| DPA60 | 20 |
|
82.8 |
