TABLE 2.

Short-Term Testicular Descent in Randomized, Placebo-Controlled Studies of LHRH

Study n Length of Follow-up Quality	LHRH Dose	LHRH Frequency	LHRH Duration	LHRH Descent, %	Placebo Descent, %
				Statistical Significance
Olsen et al 199215	400 µg	3 times daily	4 wk	9.7	1.6
n = 123
4 wk
Fair
				P = .12 (95% CI: 0.1%–16.6%)
Christiansen et al 198814	200 µg	3 times daily	4 wk	9 (bilateral cryptorchidism)	0 (bilateral cryptorchidism)
n = 220				0 (unilateral cryptorchidism)	0 (unilateral cryptorchidism)
4 wk
Fair
				NS
De Muinck Keizer-Schrama and Hazebroek et al 1986–19879–11	200 µg	3 times daily	4 wk	9.0	8.0
n = 237
8 wk
Poor
				NR
Hagberg and Westphal, 198212	100 µg	3 times daily	28 d	62.0	3.0
n = 50
4 wk
Poor
				NR
Karpe et al 198313	100 µg	6 times daily	28 d	20.0	12.0
n = 50
6 mo
Poor
				NR
Wit et al 198616	400 µg	3 times daily	28 d	37	18
n = 49
8 wk
Poor
				NR

CI, confidence interval; LHRH, luteinizing-hormone-releasing hormone; NR, not reported; NS, not significant.