Figure 5.

Plasma insulin levels (a), blood glucose levels (b) and GIR, with insulin-induced change in GIR (ΔGIR) (c) during a 2 h insulin clamp, which was preceded by a 5 h lipid infusion (5 ml kg⁻¹ h⁻¹ Intralipid + 6 U/h heparin) in conjunction with AICAR (1 mg kg⁻¹ min⁻¹) (white circles) or an equivalent volume of saline (black circles), which was infused during the last 4 h of the lipid infusion. The lipid and AICAR or saline infusions were continued throughout the clamp. (d) The effect of the above treatment on EndoR_a, (e) R_d and (f) plasma lactate levels. Data are mean±SEM for n=11–12; *p<0.05 for main effect, AICAR; ^†p<0.05 for main effect, insulin