Table 1 is formatted incorrectly. The publisher apologizes for this error. The authors have provided a corrected version here.
Table 1. Characteristics of the identified 13 cohort studies that evaluated the associations of AMD with CVD.
| Author (year) | Study name (country) | Subjects, No. | Ethnicity | Mean age (range), y | Mean BMI, kg/m2 | Men, % | Mean follow-up, y | AMD, No. | Late AMD, % | AMD assessment |
| Stroke | ||||||||||
| Ikram et al 2012 | ARIC USA | 12,216 | White/black | 59.9 (45.0-64.0) | 28.4 | 44.2 | 13.0 | 591 | 2.5 | Fundus Photography WARMGS |
| Wieberdink et al 2011 | Rotterdam Netherlands | 6,207 | White | 67.6 (61.7-74.8) | 26.0 | 40.4 | 13.6 | 2,259 | 4.1 | Fundus Photography Stage grading a |
| Hu et al 2010 | LHID Taiwan | 1,254 | Asian | 62.7 (69.0-97.0) | - | 60.3 | 5.0 | 209 | 100 | Claims database ICD-9 |
| Sun et al 2009 | CHS USA | 2,228 | White/Black | 78.4 (69.0-97.0) | 27.0 | 38.9 | 6.0 | 379 | 7.7 | Fundus Photography WARMGS |
| Tan et al 2008 | BMES Australia | 2,853 | White | 65.1 (49.0-97.0) | 26.1 | 41.3 | 11.0 | 181 | 28.2 | Fundus Photography WARMGS |
| Liao et al 2008 | Medicare USA | 1,303,186 | White/Black | 75.0 (≥65.0) | - | 40.0 | 2.0 | 137,838 | 19.7 | Claims database ICD-9 |
| Nguyen-Khoa et al 2008 | LabRx USA | 27,411 | - | 75.7 (50.0-95.0) | - | 41.1 | 2.8 | 7,203 | 100 | Claims database ICD-9 |
| Knudtson et al 2006 | BDES USA | 4,926 | White | 62.0 (43.0-84.0) | 28.8 | 43.9 | 13.2 | 988 | 8.0 | Fundus Photography WARMGS |
| CHD | ||||||||||
| Fernandez 2012 | MESA USA | 6,233 | Mixed | 62.0 (45.0-84.0) | 28.3 | 47.6 | 5.4 | 895 | 3.0 | Fundus Photography WARMGS |
| Golan 2011 | MHS Israel | 68,218 | White | 68.5 (≥65.0) | - | 41.5 | 11.0 | 6,546 | - | Claims database ICD-9 |
| Sun et al 2009 | CHS USA | 1,786 | White/black | 78.2 (69.0-97.0) | 27.0 | 34.3 | 6.0 | 302 | 8.3 | Fundus Photography WARMGS |
| Nguyen-Khoa et al 2008 | LabRx USA | 27,411 | - | 75.7 (50.0-95.0) | - | 41.1 | 2.8 | 7,203 | 100 | Claims database ICD-9 |
| Wong et al 2007 | ARIC USA | 11,414 | White/black | 59.8 (49.0-73.0) | 28.5 | 42.3 | 8.0 | 555 | 2.7 | Fundus Photography WARMGS |
| Duan et al 2007 | Medicare USA | 1,445,677 | White/black | 76.0 (≥65.0) | - | 40.0 | 2.0 | 157,579 | 19.6 | Claims database ICD-9 |
| Knudtson et al 2006 | BDES USA | 4,926 | White | 62.0 (43.0-84.0) | 28.8 | 43.9 | 13.2 | 988 | 8.0 | Fundus Photography WARMGS |
| CVD | ||||||||||
| Fernandez 2012 | MESA USA | 6,233 | Mixed | 62.0 (45.0-84.0) | 28.3 | 48.0 | 5.4 | 895 | 3.0 | Fundus Photography WARMGS |
| Tan et al 2008 | BMES Australia | 2,853 | White | 65.1 (49.0-97.0) | 26.1 | 41.3 | 11.0 | 181 | 28.2 | Fundus Photography WARMGS |
| AREDS research group 2004 | AREDS USA | 4,753 | Mostly white | 69.0 (55.0-81.0) | 27.5 | 44.2 | 6.5 | 4,753 | 20.1 | Fundus Photography AREDS |
Abbreviations: ARIC, Atherosclerosis Risk in Communities Study; MESA, Multi-Ethnic Study of Atherosclerosis; CHS, Cardiovascular Health Study; BMES, Blue Mountains Eye Study; BDES, Beaver Dam Eye Study; LHID, Longitudinal Health Insurance Database; LabRx, Ingenix LabRx Database; Medicare, Medicare beneficiaries databases; MHS, Maccabi Healthcare Services; AREDS: Age-Related Eye Disease Study; WARMGS, Wisconsin age-related maculopathy grading system; ICD-9, International Classification of Disease codes, Ninth Revision; ABP, Arterial blood pressure; HDLC, high-density lipoprotein cholesterol; LDLC, low-density lipoprotein cholesterol; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; MI, myocardial infarction; CVA, cerebrovascular accident; CRP, C-reactive protein.
AMD was graded by stage 0-4 (0, no AMD), a grading scheme similar to the WARMGS.
Reference
- 1. Wu J, Uchino M, Sastry SM, Schaumberg DA (2014) Age-Related Macular Degeneration and the Incidence of Cardiovascular Disease: A Systematic Review and Meta-Analysis. PLoS ONE 9(3): e89600 doi:10.1371/journal.pone.0089600 [DOI] [PMC free article] [PubMed] [Google Scholar]
