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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Hepatology. 2014 May 28;60(1):146–157. doi: 10.1002/hep.27036

Fig. 4. An additional deletion of STAT3 in hepatocytes increases ethanol-induced serum ALT elevation and hepatic steatosis but suppresses inflammation in ALDH2−/− mice.

Fig. 4

WT, ALDH2−/−, and ALDH2−/−STAT3Hep−/− mice were fed an ethanol diet for 10 days, followed by a single gavage of ethanol. The mice were euthanized 9 h after gavage. (A) Western blot analysis. (B) Serum ALT levels. (C) Hepatic triglyceride (TG) levels. (D) Representative hematoxylin and eosin (H&E) staining and Oil Red O staining of liver tissues. (E) The hepatic expression of cytokines was measured using real-time PCR analyses. The values in panels B, C, E represent means ± SD. (n=6 WT, n=4 ALDH2−/− or ALDH2−/−STAT3Hep−/−). *P < 0.05.