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. 1995 Jun;48(3):M118–M123. doi: 10.1136/mp.48.3.m118

Does junk DNA regulate gene expression in humans?

M A Hultén 1, M Stacey 1, S J Armstrong 1
PMCID: PMC407943  PMID: 16695991

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Selected References

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  1. Armour J. A., Jeffreys A. J. Biology and applications of human minisatellite loci. Curr Opin Genet Dev. 1992 Dec;2(6):850–856. doi: 10.1016/s0959-437x(05)80106-6. [DOI] [PubMed] [Google Scholar]
  2. Armstrong S. J., Kirkham A. J., Hultén M. A. XY chromosome behaviour in the germ-line of the human male: a FISH analysis of spatial orientation, chromatin condensation and pairing. Chromosome Res. 1994 Nov;2(6):445–452. doi: 10.1007/BF01552867. [DOI] [PubMed] [Google Scholar]
  3. Bennett S. T., Lucassen A. M., Gough S. C., Powell E. E., Undlien D. E., Pritchard L. E., Merriman M. E., Kawaguchi Y., Dronsfield M. J., Pociot F. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet. 1995 Mar;9(3):284–292. doi: 10.1038/ng0395-284. [DOI] [PubMed] [Google Scholar]
  4. Caspersson T., Zech L., Johansson C., Modest E. J. Identification of human chromosomes by DNA-binding fluorescent agents. Chromosoma. 1970;30(2):215–227. doi: 10.1007/BF00282002. [DOI] [PubMed] [Google Scholar]
  5. Choo K. H., Vissel B., Nagy A., Earle E., Kalitsis P. A survey of the genomic distribution of alpha satellite DNA on all the human chromosomes, and derivation of a new consensus sequence. Nucleic Acids Res. 1991 Mar 25;19(6):1179–1182. doi: 10.1093/nar/19.6.1179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dorer D. R., Henikoff S. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell. 1994 Jul 1;77(7):993–1002. doi: 10.1016/0092-8674(94)90439-1. [DOI] [PubMed] [Google Scholar]
  7. Green M., Krontiris T. G. Allelic variation of reporter gene activation by the HRAS1 minisatellite. Genomics. 1993 Aug;17(2):429–434. doi: 10.1006/geno.1993.1343. [DOI] [PubMed] [Google Scholar]
  8. Henikoff S. Position-effect variegation after 60 years. Trends Genet. 1990 Dec;6(12):422–426. doi: 10.1016/0168-9525(90)90304-o. [DOI] [PubMed] [Google Scholar]
  9. James T. C., Elgin S. C. Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol Cell Biol. 1986 Nov;6(11):3862–3872. doi: 10.1128/mcb.6.11.3862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jensen J. P., Hou D., Ramsburg M., Taylor A., Dean M., Weissman A. M. Organization of the human T cell receptor zeta/eta gene and its genetic linkage to the Fc gamma RII-Fc gamma RIII gene cluster. J Immunol. 1992 Apr 15;148(8):2563–2571. [PubMed] [Google Scholar]
  11. Jhanwar S. C., Burns J. P., Alonso M. L., Hew W., Chaganti R. S. Mid-pachytene chromomere maps of human autosomes. Cytogenet Cell Genet. 1982;33(3):240–248. doi: 10.1159/000131760. [DOI] [PubMed] [Google Scholar]
  12. Kobayashi K., Mizuno K., Hida A., Komaki R., Tomita K., Matsushita I., Namiki M., Iwamoto T., Tamura S., Minowada S. PCR analysis of the Y chromosome long arm in azoospermic patients: evidence for a second locus required for spermatogenesis. Hum Mol Genet. 1994 Nov;3(11):1965–1967. doi: 10.1093/hmg/3.11.1965. [DOI] [PubMed] [Google Scholar]
  13. Krontiris T. G., Devlin B., Karp D. D., Robert N. J., Risch N. An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med. 1993 Aug 19;329(8):517–523. doi: 10.1056/NEJM199308193290801. [DOI] [PubMed] [Google Scholar]
  14. Miwa S. Triplet repeats strike again. Nat Genet. 1994 Jan;6(1):3–4. doi: 10.1038/ng0194-3. [DOI] [PubMed] [Google Scholar]
  15. Pearson P. L., Bobrow M. Fluorescent staining of the Y chromosome in meiotic stages of the human male. J Reprod Fertil. 1970 Jun;22(1):177–179. doi: 10.1530/jrf.0.0220177. [DOI] [PubMed] [Google Scholar]
  16. Pérez M. M., Míguez L., Fuster C., Miró R., Genescà G., Egozcue J. Heterochromatin decondensation in chromosomes from chorionic villus samples. Prenat Diagn. 1991 Sep;11(9):697–704. doi: 10.1002/pd.1970110906. [DOI] [PubMed] [Google Scholar]
  17. Rattner J. B., Lin C. C. Radial loops and helical coils coexist in metaphase chromosomes. Cell. 1985 Aug;42(1):291–296. doi: 10.1016/s0092-8674(85)80124-0. [DOI] [PubMed] [Google Scholar]
  18. Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971 Oct 30;2(7731):971–972. doi: 10.1016/s0140-6736(71)90287-x. [DOI] [PubMed] [Google Scholar]
  19. Shaffer C. D., Wallrath L. L., Elgin S. C. Regulating genes by packaging domains: bits of heterochromatin in euchromatin? Trends Genet. 1993 Feb;9(2):35–37. doi: 10.1016/0168-9525(93)90171-D. [DOI] [PubMed] [Google Scholar]
  20. Smeets D. F., Moog U., Weemaes C. M., Vaes-Peeters G., Merkx G. F., Niehof J. P., Hamers G. ICF syndrome: a new case and review of the literature. Hum Genet. 1994 Sep;94(3):240–246. doi: 10.1007/BF00208277. [DOI] [PubMed] [Google Scholar]
  21. Tartof K. D., Henikoff S. Trans-sensing effects from Drosophila to humans. Cell. 1991 Apr 19;65(2):201–203. doi: 10.1016/0092-8674(91)90153-p. [DOI] [PubMed] [Google Scholar]
  22. Tiepolo L., Maraschio P., Gimelli G., Cuoco C., Gargani G. F., Romano C. Multibranched chromosomes 1, 9, and 16 in a patient with combined IgA and IgE deficiency. Hum Genet. 1979 Oct 1;51(2):127–137. doi: 10.1007/BF00287166. [DOI] [PubMed] [Google Scholar]
  23. Vogt P. Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved "chromatin folding code". Hum Genet. 1990 Mar;84(4):301–336. doi: 10.1007/BF00196228. [DOI] [PubMed] [Google Scholar]
  24. Weissman A. M., Hou D., Orloff D. G., Modi W. S., Seuanez H., O'Brien S. J., Klausner R. D. Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9709–9713. doi: 10.1073/pnas.85.24.9709. [DOI] [PMC free article] [PubMed] [Google Scholar]

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