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. 1996 Aug;49(4):M185–M191. doi: 10.1136/mp.49.4.m185

Karyotypic and molecular abnormalities in chronic lymphocytic leukaemia

C D Fegan 1,2, F E Davies 1,2
PMCID: PMC408056  PMID: 16696072

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M185

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adachi M., Cossman J., Longo D., Croce C. M., Tsujimoto Y. Variant translocation of the bcl-2 gene to immunoglobulin lambda light chain gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2771–2774. doi: 10.1073/pnas.86.8.2771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adachi M., Tefferi A., Greipp P. R., Kipps T. J., Tsujimoto Y. Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia. J Exp Med. 1990 Feb 1;171(2):559–564. doi: 10.1084/jem.171.2.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Adachi M., Tsujimoto Y. Juxtaposition of human bcl-2 and immunoglobulin lambda light chain gene in chronic lymphocytic leukemia is the result of a reciprocal chromosome translocation between chromosome 18 and 22. Oncogene. 1989 Sep;4(9):1073–1075. [PubMed] [Google Scholar]
  4. Anastasi J., Le Beau M. M., Vardiman J. W., Fernald A. A., Larson R. A., Rowley J. D. Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method. Blood. 1992 Apr 1;79(7):1796–1801. [PubMed] [Google Scholar]
  5. Armitage J. O., Sanger W. G., Weisenburger D. D., Harrington D. S., Linder J., Bierman P. J., Vose J. M., Purtilo D. T. Correlation of secondary cytogenetic abnormalities with histologic appearance in non-Hodgkin's lymphomas bearing t(14;18)(q32;q21). J Natl Cancer Inst. 1988 Jun 15;80(8):576–580. doi: 10.1093/jnci/80.8.576. [DOI] [PubMed] [Google Scholar]
  6. Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A., Gralnick H. R., Sultan C. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group. J Clin Pathol. 1989 Jun;42(6):567–584. doi: 10.1136/jcp.42.6.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bienz N., Cardy D. L., Leyland M. J., Hultén M. A. Trisomy 12 in B-cell chronic lymphocytic leukaemia: an evaluation of 33 patients by direct fluorescence in situ hybridization (FISH). Br J Haematol. 1993 Dec;85(4):819–822. doi: 10.1111/j.1365-2141.1993.tb03233.x. [DOI] [PubMed] [Google Scholar]
  8. Bird M. L., Ueshima Y., Rowley J. D., Haren J. M., Vardiman J. W. Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations. Leukemia. 1989 Mar;3(3):182–191. [PubMed] [Google Scholar]
  9. Brown A. G., Ross F. M., Dunne E. M., Steel C. M., Weir-Thompson E. M. Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene. Nat Genet. 1993 Jan;3(1):67–72. doi: 10.1038/ng0193-67. [DOI] [PubMed] [Google Scholar]
  10. Bueso-Ramos C. E., Manshouri T., Haidar M. A., Huh Y. O., Keating M. J., Albitar M. Multiple patterns of MDM-2 deregulation in human leukemias: implications in leukemogenesis and prognosis. Leuk Lymphoma. 1995 Mar;17(1-2):13–18. doi: 10.3109/10428199509051698. [DOI] [PubMed] [Google Scholar]
  11. Buschle M., Campana D., Carding S. R., Richard C., Hoffbrand A. V., Brenner M. K. Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia. J Exp Med. 1993 Jan 1;177(1):213–218. doi: 10.1084/jem.177.1.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Butturini A., Gale R. P. Oncogenes in chronic lymphocytic leukemia. Leuk Res. 1988;12(1):89–92. doi: 10.1016/s0145-2126(98)80013-1. [DOI] [PubMed] [Google Scholar]
  13. Caron de Fromentel C., Soussi T. TP53 tumor suppressor gene: a model for investigating human mutagenesis. Genes Chromosomes Cancer. 1992 Jan;4(1):1–15. doi: 10.1002/gcc.2870040102. [DOI] [PubMed] [Google Scholar]
  14. Catovsky D., Fooks J., Richards S. Prognostic factors in chronic lymphocytic leukaemia: the importance of age, sex and response to treatment in survival. A report from the MRC CLL 1 trial. MRC Working Party on Leukaemia in Adults. Br J Haematol. 1989 Jun;72(2):141–149. doi: 10.1111/j.1365-2141.1989.tb07674.x. [DOI] [PubMed] [Google Scholar]
  15. Chapman R. M., Corcoran M. M., Gardiner A., Hawthorn L. A., Cowell J. K., Oscier D. G. Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia. Oncogene. 1994 Apr;9(4):1289–1293. [PubMed] [Google Scholar]
  16. Cleary M. L., Galili N., Sklar J. Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J Exp Med. 1986 Jul 1;164(1):315–320. doi: 10.1084/jem.164.1.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Cleary M. L., Sklar J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7439–7443. doi: 10.1073/pnas.82.21.7439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Criel A., Wlodarska I., Meeus P., Stul M., Louwagie A., Van Hoof A., Hidajat M., Mecucci C., Van den Berghe H. Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias. Br J Haematol. 1994 Jul;87(3):523–528. doi: 10.1111/j.1365-2141.1994.tb08307.x. [DOI] [PubMed] [Google Scholar]
  19. Crossen P. E., Horn H. L. Origin of trisomy 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 1987 Sep;28(1):185–186. doi: 10.1016/0165-4608(87)90371-2. [DOI] [PubMed] [Google Scholar]
  20. Cuneo A., Balboni M., Piva N., Rigolin G. M., Roberti M. G., Mejak C., Moretti S., Bigoni R., Balsamo R., Cavazzini P. Atypical chronic lymphocytic leukaemia with t(11;14)(q13;q32): karyotype evolution and prolymphocytic transformation. Br J Haematol. 1995 Jun;90(2):409–416. doi: 10.1111/j.1365-2141.1995.tb05167.x. [DOI] [PubMed] [Google Scholar]
  21. Cuneo A., de Angeli C., Roberti M. G., Piva N., Bigoni R., Gandini D., Rigolin G. M., Moretti S., Cavazzini P., del Senno L. Richter's syndrome in a case of atypical chronic lymphocytic leukaemia with the t(11;14)(q13;q32): role for a p53 exon 7 gene mutation. Br J Haematol. 1996 Feb;92(2):375–381. doi: 10.1046/j.1365-2141.1996.d01-1505.x. [DOI] [PubMed] [Google Scholar]
  22. Dancescu M., Rubio-Trujillo M., Biron G., Bron D., Delespesse G., Sarfati M. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med. 1992 Nov 1;176(5):1319–1326. doi: 10.1084/jem.176.5.1319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Dyer M. J., Zani V. J., Lu W. Z., O'Byrne A., Mould S., Chapman R., Heward J. M., Kayano H., Jadayel D., Matutes E. BCL2 translocations in leukemias of mature B cells. Blood. 1994 Jun 15;83(12):3682–3688. [PubMed] [Google Scholar]
  24. Fegan C., Robinson H., Thompson P., Whittaker J. A., White D. Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease. Leukemia. 1995 Dec;9(12):2003–2008. [PubMed] [Google Scholar]
  25. Fenaux P., Preudhomme C., Laï J. L., Quiquandon I., Jonveaux P., Vanrumbeke M., Sartiaux C., Morel P., Loucheux-Lefebvre M. H., Bauters F. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis. Leukemia. 1992 Apr;6(4):246–250. [PubMed] [Google Scholar]
  26. Fitchett M., Griffiths M. J., Oscier D. G., Johnson S., Seabright M. Chromosome abnormalities involving band 13q14 in hematologic malignancies. Cancer Genet Cytogenet. 1987 Jan;24(1):143–150. doi: 10.1016/0165-4608(87)90091-4. [DOI] [PubMed] [Google Scholar]
  27. Foon K. A., Rai K. R., Gale R. P. Chronic lymphocytic leukemia: new insights into biology and therapy. Ann Intern Med. 1990 Oct 1;113(7):525–539. doi: 10.7326/0003-4819-113-7-525. [DOI] [PubMed] [Google Scholar]
  28. Gahrton G., Robèrt K. H., Friberg K., Zech L., Bird A. G. Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation. Blood. 1980 Oct;56(4):640–647. [PubMed] [Google Scholar]
  29. Gahrton G., Zech L., Robèrt K. H., Bird A. G. Mitogenic stimulation of leukemia cells by Epstein-Barr virus. N Engl J Med. 1979 Aug 23;301(8):438–439. doi: 10.1056/nejm197908233010823. [DOI] [PubMed] [Google Scholar]
  30. Gaidano G., Ballerini P., Gong J. Z., Inghirami G., Neri A., Newcomb E. W., Magrath I. T., Knowles D. M., Dalla-Favera R. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5413–5417. doi: 10.1073/pnas.88.12.5413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Gaidano G., Newcomb E. W., Gong J. Z., Tassi V., Neri A., Cortelezzi A., Calori R., Baldini L., Dalla-Favera R. Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia. Am J Pathol. 1994 Jun;144(6):1312–1319. [PMC free article] [PubMed] [Google Scholar]
  32. Gandini D., Aguiari G. L., Cuneo A., Piva R., Castoldi G. L., del Senno L. Novel small deletions of the p53 gene in late-stage B-cell chronic lymphocytic leukaemia. Br J Haematol. 1994 Dec;88(4):881–885. doi: 10.1111/j.1365-2141.1994.tb05132.x. [DOI] [PubMed] [Google Scholar]
  33. Garcìa-Marco J., Matutes E., Morilla R., Ellis J., Oscier D., Fantes J., Catovsky D., Price C. M. Trisomy 12 in B-cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization. Br J Haematol. 1994 May;87(1):44–50. doi: 10.1111/j.1365-2141.1994.tb04868.x. [DOI] [PubMed] [Google Scholar]
  34. Han T., Ohtaki K., Sadamori N., Block A. W., Dadey B., Ozer H., Sandberg A. A. Cytogenetic evidence for clonal evolution in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 1986 Dec;23(4):321–328. doi: 10.1016/0165-4608(86)90015-4. [DOI] [PubMed] [Google Scholar]
  35. Han T., Ozer H., Sadamori N., Emrich L., Gomez G. A., Henderson E. S., Bloom M. L., Sandberg A. A. Prognostic importance of cytogenetic abnormalities in patients with chronic lymphocytic leukemia. N Engl J Med. 1984 Feb 2;310(5):288–292. doi: 10.1056/NEJM198402023100504. [DOI] [PubMed] [Google Scholar]
  36. Hanada M., Delia D., Aiello A., Stadtmauer E., Reed J. C. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood. 1993 Sep 15;82(6):1820–1828. [PubMed] [Google Scholar]
  37. Hawthorn L. A., Chapman R., Oscier D., Cowell J. K. The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene. Oncogene. 1993 Jun;8(6):1415–1419. [PubMed] [Google Scholar]
  38. Heim S., Mitelman F. Cytogenetically unrelated clones in hematological neoplasms. Leukemia. 1989 Jan;3(1):6–8. [PubMed] [Google Scholar]
  39. Hernandez J. M., Mecucci C., Criel A., Meeus P., Michaux I., Van Hoof A., Verhoef G., Louwagie A., Scheiff J. M., Michaux J. L. Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria. Leukemia. 1995 Dec;9(12):2140–2146. [PubMed] [Google Scholar]
  40. Jabbar S. A., Ganeshaguru K., Wickremasinghe R. G., Hoffbrand A. V., Foroni L. Deletion of chromosome 13 (band q14) but not trisomy 12 is a clonal event in B-chronic lymphocytic leukaemia (CLL). Br J Haematol. 1995 Jun;90(2):476–478. doi: 10.1111/j.1365-2141.1995.tb05180.x. [DOI] [PubMed] [Google Scholar]
  41. Jewell A. P., Worman C. P., Lydyard P. M., Yong K. L., Giles F. J., Goldstone A. H. Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo. Br J Haematol. 1994 Oct;88(2):268–274. doi: 10.1111/j.1365-2141.1994.tb05017.x. [DOI] [PubMed] [Google Scholar]
  42. Jonveaux P., Hillion J., Bennaceur A. L., d'Agay M. F., Brice P., Daniel M. T., Sigaux F., Berger R. t(14;18) and bcl-2 gene rearrangement in a B-chronic lymphocytic leukaemia. Br J Haematol. 1992 Aug;81(4):620–621. doi: 10.1111/j.1365-2141.1992.tb03006.x. [DOI] [PubMed] [Google Scholar]
  43. Juliusson G., Friberg K., Gahrton G. Consistency of chromosomal aberrations in chronic B-lymphocytic leukemia. A longitudinal cytogenetic study of 41 patients. Cancer. 1988 Aug 1;62(3):500–506. doi: 10.1002/1097-0142(19880801)62:3<500::aid-cncr2820620310>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  44. Juliusson G., Gahrton G. Cytogenetics in CLL and related disorders. Baillieres Clin Haematol. 1993 Dec;6(4):821–848. doi: 10.1016/s0950-3536(05)80178-7. [DOI] [PubMed] [Google Scholar]
  45. Juliusson G., Gahrton G., Einhorn S., Liu Y., Oscier D. G., Chapman R. Chromosome abnormalities and RB1 gene deletions in chronic lymphocytic leukemia. Blood. 1993 Sep 15;82(6):1938–1939. [PubMed] [Google Scholar]
  46. Juliusson G., Oscier D. G., Fitchett M., Ross F. M., Stockdill G., Mackie M. J., Parker A. C., Castoldi G. L., Guneo A., Knuutila S. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med. 1990 Sep 13;323(11):720–724. doi: 10.1056/NEJM199009133231105. [DOI] [PubMed] [Google Scholar]
  47. Juliusson G., Robèrt K. H., Ost A., Friberg K., Biberfeld P., Nilsson B., Zech L., Gahrton G. Prognostic information from cytogenetic analysis in chronic B-lymphocytic leukemia and leukemic immunocytoma. Blood. 1985 Jan;65(1):134–141. [PubMed] [Google Scholar]
  48. Kay N. E., Ranheim E. A., Peterson L. C. Tumor suppressor genes and clonal evolution in B-CLL. Leuk Lymphoma. 1995 Jun;18(1-2):41–49. doi: 10.3109/10428199509064921. [DOI] [PubMed] [Google Scholar]
  49. Kay N. E., Suen R., Ranheim E., Peterson L. C. Confirmation of Rb gene defects in B-CLL clones and evidence for variable predominance of the Rb defective cells within the CLL clone. Br J Haematol. 1993 Jun;84(2):257–264. doi: 10.1111/j.1365-2141.1993.tb03061.x. [DOI] [PubMed] [Google Scholar]
  50. Kornblau S. M., Chen N., del Giglio A., O'Brien S., Deisseroth A. B. Retinoblastoma protein expression is frequently altered in chronic lymphocytic leukemia. Cancer Res. 1994 Jan 1;54(1):242–246. [PubMed] [Google Scholar]
  51. Lane D. P. Cancer. p53, guardian of the genome. Nature. 1992 Jul 2;358(6381):15–16. doi: 10.1038/358015a0. [DOI] [PubMed] [Google Scholar]
  52. Lane D. P., Crawford L. V. T antigen is bound to a host protein in SV40-transformed cells. Nature. 1979 Mar 15;278(5701):261–263. doi: 10.1038/278261a0. [DOI] [PubMed] [Google Scholar]
  53. Levine A. J., Momand J., Finlay C. A. The p53 tumour suppressor gene. Nature. 1991 Jun 6;351(6326):453–456. doi: 10.1038/351453a0. [DOI] [PubMed] [Google Scholar]
  54. Liu Y., Grandér D., Söderhäll S., Juliusson G., Gahrton G., Einhorn S. Retinoblastoma gene deletions in B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer. 1992 Apr;4(3):250–256. doi: 10.1002/gcc.2870040310. [DOI] [PubMed] [Google Scholar]
  55. Liu Y., Hermanson M., Grandér D., Merup M., Wu X., Heyman M., Rasool O., Juliusson G., Gahrton G., Detlofsson R. 13q deletions in lymphoid malignancies. Blood. 1995 Sep 1;86(5):1911–1915. [PubMed] [Google Scholar]
  56. Liu Y., Szekely L., Grandér D., Söderhäll S., Juliusson G., Gahrton G., Linder S., Einhorn S. Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8697–8701. doi: 10.1073/pnas.90.18.8697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Losada A. P., Wessman M., Tiainen M., Hopman A. H., Willard H. F., Solé F., Caballín M. R., Woessner S., Knuutila S. Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study. Blood. 1991 Aug 1;78(3):775–779. [PubMed] [Google Scholar]
  58. Lowe S. W., Ruley H. E., Jacks T., Housman D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993 Sep 24;74(6):957–967. doi: 10.1016/0092-8674(93)90719-7. [DOI] [PubMed] [Google Scholar]
  59. Mariano M. T., Moretti L., Donelli A., Grantini M., Montagnani G., Di Prisco A. U., Torelli G., Torelli U., Narni F. bcl-2 gene expression in hematopoietic cell differentiation. Blood. 1992 Aug 1;80(3):768–775. [PubMed] [Google Scholar]
  60. Matolcsy A., Inghirami G., Knowles D. M. Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma). Blood. 1994 Mar 1;83(5):1363–1372. [PubMed] [Google Scholar]
  61. Matutes E., Oscier D., Garcia-Marco J., Ellis J., Copplestone A., Gillingham R., Hamblin T., Lens D., Swansbury G. J., Catovsky D. Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients. Br J Haematol. 1996 Feb;92(2):382–388. doi: 10.1046/j.1365-2141.1996.d01-1478.x. [DOI] [PubMed] [Google Scholar]
  62. Matutes E., Owusu-Ankomah K., Morilla R., Garcia Marco J., Houlihan A., Que T. H., Catovsky D. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994 Oct;8(10):1640–1645. [PubMed] [Google Scholar]
  63. Mecucci C., Delannoy A., Van den Berghe H. The origin of trisomy 12 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 1988 Dec;36(2):203–204. doi: 10.1016/0165-4608(88)90146-x. [DOI] [PubMed] [Google Scholar]
  64. Meeker T. C., Grimaldi J. C., O'Rourke R., Louie E., Juliusson G., Einhorn S. An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy. Blood. 1989 Oct;74(5):1801–1806. [PubMed] [Google Scholar]
  65. Momand J., Zambetti G. P., Olson D. C., George D., Levine A. J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 1992 Jun 26;69(7):1237–1245. doi: 10.1016/0092-8674(92)90644-r. [DOI] [PubMed] [Google Scholar]
  66. Neubauer A., Richiero K., Huhn D. Alterations of the retinoblastoma a susceptibility gene in chronic lymphocytic leukemia. Leuk Lymphoma. 1995 Aug;18(5-6):399–404. doi: 10.3109/10428199509059637. [DOI] [PubMed] [Google Scholar]
  67. Newman R. A., Peterson B., Davey F. R., Brabyn C., Collins H., Brunetto V. L., Duggan D. B., Weiss R. B., Royston I., Millard F. E. Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study. Blood. 1993 Aug 15;82(4):1239–1246. [PubMed] [Google Scholar]
  68. Nowell P. C., Moreau L., Growney P., Besa E. C. Karyotypic stability in chronic B-cell leukemia. Cancer Genet Cytogenet. 1988 Jul 15;33(2):155–160. doi: 10.1016/0165-4608(88)90025-8. [DOI] [PubMed] [Google Scholar]
  69. Offit K., Louie D. C., Parsa N. Z., Filippa D., Gangi M., Siebert R., Chaganti R. S. Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23). Blood. 1994 May 1;83(9):2611–2618. [PubMed] [Google Scholar]
  70. Offit K., Parsa N. Z., Gaidano G., Filippa D. A., Louie D., Pan D., Jhanwar S. C., Dalla-Favera R., Chaganti R. S. 6q deletions define distinct clinico-pathologic subsets of non-Hodgkin's lymphoma. Blood. 1993 Oct 1;82(7):2157–2162. [PubMed] [Google Scholar]
  71. Oscier D. G. Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia. Blood Rev. 1994 Jun;8(2):88–97. doi: 10.1016/s0268-960x(05)80013-x. [DOI] [PubMed] [Google Scholar]
  72. Oscier D. G., Stevens J., Hamblin T. J., Pickering R. M., Lambert R., Fitchett M. Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia. Br J Haematol. 1990 Nov;76(3):352–358. doi: 10.1111/j.1365-2141.1990.tb06367.x. [DOI] [PubMed] [Google Scholar]
  73. Oscier D., Fitchett M., Herbert T., Lambert R. Karyotypic evolution in B-cell chronic lymphocytic leukaemia. Genes Chromosomes Cancer. 1991 Jan;3(1):16–20. doi: 10.1002/gcc.2870030104. [DOI] [PubMed] [Google Scholar]
  74. Peterson L. C., Lindquist L. L., Church S., Kay N. E. Frequent clonal abnormalities of chromosome band 13q14 in B-cell chronic lymphocytic leukemia: multiple clones, subclones, and nonclonal alterations in 82 midwestern patients. Genes Chromosomes Cancer. 1992 Jun;4(4):273–280. doi: 10.1002/gcc.2870040402. [DOI] [PubMed] [Google Scholar]
  75. Philip P., Geisler C., Hansen M. M., Hasselbalch H., Christensen B. E., Drivsholm A., Lund B., Nielsen J. B., Jensen K. B., Andersen E. Aberrations of chromosome 6 in 193 newly diagnosed untreated cases of chronic lymphocytic leukemia. Cancer Genet Cytogenet. 1991 May;53(1):35–43. doi: 10.1016/0165-4608(91)90112-8. [DOI] [PubMed] [Google Scholar]
  76. Pittman S., Catovsky D. Chromosome abnormalities in B-cell prolymphocytic leukemia: a study of nine cases. Cancer Genet Cytogenet. 1983 Aug;9(4):355–365. doi: 10.1016/0165-4608(83)90084-5. [DOI] [PubMed] [Google Scholar]
  77. Pittman S., Catovsky D. Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia. Br J Haematol. 1984 Dec;58(4):649–660. doi: 10.1111/j.1365-2141.1984.tb06112.x. [DOI] [PubMed] [Google Scholar]
  78. Que T. H., Marco J. G., Ellis J., Matutes E., Babapulle V. B., Boyle S., Catovsky D. Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype, and morphology. Blood. 1993 Jul 15;82(2):571–575. [PubMed] [Google Scholar]
  79. Raffeld M., Jaffe E. S. bcl-1, t(11;14), and mantle cell-derived lymphomas. Blood. 1991 Jul 15;78(2):259–263. [PubMed] [Google Scholar]
  80. Raghoebier S., van Krieken J. H., Kluin-Nelemans J. C., Gillis A., van Ommen G. J., Ginsberg A. M., Raffeld M., Kluin P. M. Oncogene rearrangements in chronic B-cell leukemia. Blood. 1991 Apr 1;77(7):1560–1564. [PubMed] [Google Scholar]
  81. Rechavi G., Katzir N., Brok-Simoni F., Holtzman F., Mandel M., Gurfinkel N., Givol D., Ben-Bassat I., Ramot B. A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia. Leukemia. 1989 Jan;3(1):57–60. [PubMed] [Google Scholar]
  82. Richardson M. E., Chen Q. G., Filippa D. A., Offit K., Hampton A., Koduru P. R., Jhanwar S. C., Lieberman P. H., Clarkson B. D., Chaganti R. S. Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes. Blood. 1987 Aug;70(2):444–447. [PubMed] [Google Scholar]
  83. Ridge S. A., Dyer M., Greaves M. F., Wiedemann L. M. Lack of MDM2 amplification in human leukaemia. Br J Haematol. 1994 Feb;86(2):407–409. doi: 10.1111/j.1365-2141.1994.tb04754.x. [DOI] [PubMed] [Google Scholar]
  84. Rimokh R., Berger F., Bastard C., Klein B., French M., Archimbaud E., Rouault J. P., Santa Lucia B., Duret L., Vuillaume M. Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood. 1994 Jun 15;83(12):3689–3696. [PubMed] [Google Scholar]
  85. Robèrt K. H., Möller E., Gahrton G., Eriksson H., Nilsson B. B-cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia. Clin Exp Immunol. 1978 Aug;33(2):302–308. [PMC free article] [PubMed] [Google Scholar]
  86. Schena M., Larsson L. G., Gottardi D., Gaidano G., Carlsson M., Nilsson K., Caligaris-Cappio F. Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood. 1992 Jun 1;79(11):2981–2989. [PubMed] [Google Scholar]
  87. Tashiro S., Takechi M., Asou H., Takauchi K., Kyo T., Dohy H., Kikuchi M., Kamada N., Tsujimoto Y. Cytogenetic 2; 18 and 18; 22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes. Oncogene. 1992 Mar;7(3):573–577. [PubMed] [Google Scholar]
  88. Vandenberghe E., De Wolf Peeters C., Wlodarska I., Stul M., Louwagie A., Verhoef G., Thomas J., Criel A., Cassiman J. J., Mecucci C. Chromosome 11q rearrangements in B non Hodgkin's lymphoma. Br J Haematol. 1992 Jun;81(2):212–217. doi: 10.1111/j.1365-2141.1992.tb08209.x. [DOI] [PubMed] [Google Scholar]
  89. Vogelstein B., Kinzler K. W. p53 function and dysfunction. Cell. 1992 Aug 21;70(4):523–526. doi: 10.1016/0092-8674(92)90421-8. [DOI] [PubMed] [Google Scholar]
  90. Watanabe T., Hotta T., Ichikawa A., Kinoshita T., Nagai H., Uchida T., Murate T., Saito H. The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood. 1994 Nov 1;84(9):3158–3165. [PubMed] [Google Scholar]
  91. Wattel E., Preudhomme C., Hecquet B., Vanrumbeke M., Quesnel B., Dervite I., Morel P., Fenaux P. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood. 1994 Nov 1;84(9):3148–3157. [PubMed] [Google Scholar]
  92. Witzig T. E., Borell T. J., Herath J. F., Tefferi A., Li C. Y., Jenkins R. B. Detection of trisomy 12 by FISH in untreated B-chronic lymphocytic leukemia: correlation with stage and CD20 antigen expression intensity. Leuk Lymphoma. 1994 Aug;14(5-6):447–451. doi: 10.3109/10428199409049702. [DOI] [PubMed] [Google Scholar]
  93. Young B. D. Cytogenetic and molecular analysis of chromosome 11q23 abnormalities in leukaemia. Baillieres Clin Haematol. 1992 Oct;5(4):881–895. doi: 10.1016/s0950-3536(11)80050-8. [DOI] [PubMed] [Google Scholar]
  94. de Boer C. J., Schuuring E., Dreef E., Peters G., Bartek J., Kluin P. M., van Krieken J. H. Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma. Blood. 1995 Oct 1;86(7):2715–2723. [PubMed] [Google Scholar]
  95. el Rouby S., Bayona W., Pisharody S. M., Newcomb E. W. p53 mutations in B-cell chronic lymphocytic leukemia. Curr Top Microbiol Immunol. 1992;182:313–317. doi: 10.1007/978-3-642-77633-5_39. [DOI] [PubMed] [Google Scholar]
  96. el Rouby S., Thomas A., Costin D., Rosenberg C. R., Potmesil M., Silber R., Newcomb E. W. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood. 1993 Dec 1;82(11):3452–3459. [PubMed] [Google Scholar]

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