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. 1996 Aug;49(4):M192–M198. doi: 10.1136/mp.49.4.m192

The invasiveness of Entamoeba histolytica - a continuing enigma

J P Ackers 1
PMCID: PMC408057  PMID: 16696073

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M192

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson M., Gunne H., Agerberth B., Boman A., Bergman T., Sillard R., Jörnvall H., Mutt V., Olsson B., Wigzell H. NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity. EMBO J. 1995 Apr 18;14(8):1615–1625. doi: 10.1002/j.1460-2075.1995.tb07150.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arroyo R., Orozco E. Localization and identification of an Entamoeba histolytica adhesin. Mol Biochem Parasitol. 1987 Mar;23(2):151–158. doi: 10.1016/0166-6851(87)90150-2. [DOI] [PubMed] [Google Scholar]
  3. Avila E. E., Sánchez-Garza M., Calderón J. Entamoeba histolytica and E. invadens: sulfhydryl-dependent proteolytic activity. J Protozool. 1985 Feb;32(1):163–166. doi: 10.1111/j.1550-7408.1985.tb03032.x. [DOI] [PubMed] [Google Scholar]
  4. Bailey G. B., Day D. B., Nokkaew C., Harper C. C. Stimulation by target cell membrane lipid of actin polymerization and phagocytosis by Entamoeba histolytica. Infect Immun. 1987 Aug;55(8):1848–1853. doi: 10.1128/iai.55.8.1848-1853.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bailey G. B., Nudelman E. D., Day D. B., Harper C. F., Gilmour J. R. Specificity of glycosphingolipid recognition by Entamoeba histolytica trophozoites. Infect Immun. 1990 Jan;58(1):43–47. doi: 10.1128/iai.58.1.43-47.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bailey G. B., Shen P. S., Beanan M. J., McCoomer N. E. Actin associated proteins of Entamoeba histolytica. Arch Med Res. 1992;23(2):129–132. [PubMed] [Google Scholar]
  7. Bhattacharya S., Bhattacharya A., Diamond L. S., Soldo A. T. Circular DNA of Entamoeba histolytica encodes ribosomal RNA. J Protozool. 1989 Sep-Oct;36(5):455–458. doi: 10.1111/j.1550-7408.1989.tb01080.x. [DOI] [PubMed] [Google Scholar]
  8. Binder M., Ortner S., Erben H., Scheiner O., Wiedermann G., Valenta R., Duchêne M. The basic isoform of profilin in pathogenic Entamoeba histolytica. cDNA cloning, heterologous expression, and actin-binding properties. Eur J Biochem. 1995 Nov 1;233(3):976–981. doi: 10.1111/j.1432-1033.1995.976_3.x. [DOI] [PubMed] [Google Scholar]
  9. Blakely P., Sargeaunt P. G., Reed S. L. An immunogenic 30-kDa surface antigen of pathogenic clinical isolates of Entamoeba histolytica. J Infect Dis. 1990 Oct;162(4):949–954. doi: 10.1093/infdis/162.4.949. [DOI] [PubMed] [Google Scholar]
  10. Bos H. J. The problem of pathogenicity in parasitic entamoeba. Acta Leiden. 1973;40:5–111. [PubMed] [Google Scholar]
  11. Bracha R., Mirelman D. Virulence of Entamoeba histolytica trophozoites. Effects of bacteria, microaerobic conditions, and metronidazole. J Exp Med. 1984 Aug 1;160(2):353–368. doi: 10.1084/jem.160.2.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Braga L. L., Ninomiya H., McCoy J. J., Eacker S., Wiedmer T., Pham C., Wood S., Sims P. J., Petri W. A., Jr Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica. J Clin Invest. 1992 Sep;90(3):1131–1137. doi: 10.1172/JCI115931. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Bruchhaus I., Tannich E. A gene highly homologous to ACP1 encoding cysteine proteinase 3 in Entamoeba histolytica is present and expressed in E. dispar. Parasitol Res. 1996;82(2):189–192. doi: 10.1007/s004360050093. [DOI] [PubMed] [Google Scholar]
  14. Bruckner D. A. Amebiasis. Clin Microbiol Rev. 1992 Oct;5(4):356–369. doi: 10.1128/cmr.5.4.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Burchard G. D., Prange G., Mirelman D. Interaction of various Entamoeba histolytica strains with human intestinal cell lines. Arch Med Res. 1992;23(2):193–195. [PubMed] [Google Scholar]
  16. Caballero-Salcedo A., Viveros-Rogel M., Salvatierra B., Tapia-Conyer R., Sepulveda-Amor J., Gutierrez G., Ortiz-Ortiz L. Seroepidemiology of amebiasis in Mexico. Am J Trop Med Hyg. 1994 Apr;50(4):412–419. doi: 10.4269/ajtmh.1994.50.412. [DOI] [PubMed] [Google Scholar]
  17. Cano-Mancera R., López-Revilla R. Inhibition of the adhesion of Entamoeba histolytica trophozoites to human erythrocytes by carbohydrates. Parasitol Res. 1987;74(1):18–22. doi: 10.1007/BF00534926. [DOI] [PubMed] [Google Scholar]
  18. Chadee K., Meerovitch E. Entamoeba histolytica: early progressive pathology in the cecum of the gerbil (Meriones unguiculatus). Am J Trop Med Hyg. 1985 Mar;34(2):283–291. doi: 10.4269/ajtmh.1985.34.283. [DOI] [PubMed] [Google Scholar]
  19. Chadee K., Petri W. A., Jr, Innes D. J., Ravdin J. I. Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica. J Clin Invest. 1987 Nov;80(5):1245–1254. doi: 10.1172/JCI113199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Charmot G. Existe-il des souches hépatotropes d'Entamoeba histolytica? Bull Soc Pathol Exot Filiales. 1980 Jul-Aug;73(4):405–410. [PubMed] [Google Scholar]
  21. Clark C. G. Axenic cultivation of Entamoeba dispar Brumpt 1925, Entamoeba insolita Geiman and Wichterman 1937 and Entamoeba ranarum Grassi 1879. J Eukaryot Microbiol. 1995 Sep-Oct;42(5):590–593. doi: 10.1111/j.1550-7408.1995.tb05912.x. [DOI] [PubMed] [Google Scholar]
  22. Clark C. G., Diamond L. S. Pathogenicity, virulence and Entamoeba histolytica. Parasitol Today. 1994 Feb;10(2):46–47. doi: 10.1016/0169-4758(94)90389-1. [DOI] [PubMed] [Google Scholar]
  23. Clark C. G., Diamond L. S. The Laredo strain and other 'Entamoeba histolytica-like' amoebae are Entamoeba moshkovskii. Mol Biochem Parasitol. 1991 May;46(1):11–18. doi: 10.1016/0166-6851(91)90194-b. [DOI] [PubMed] [Google Scholar]
  24. Diamond L. S. Amebiasis: a problem solved. What now? Bernardo Sepúlveda Memorial lecture. Arch Med Res. 1992 Winter;23(4):157–161. [PubMed] [Google Scholar]
  25. Diamond L. S., Clark C. G. A redescription of Entamoeba histolytica Schaudinn, 1903 (Emended Walker, 1911) separating it from Entamoeba dispar Brumpt, 1925. J Eukaryot Microbiol. 1993 May-Jun;40(3):340–344. doi: 10.1111/j.1550-7408.1993.tb04926.x. [DOI] [PubMed] [Google Scholar]
  26. Diamond L. S., Clark C. G., Cunnick C. C. YI-S, a casein-free medium for axenic cultivation of Entamoeba histolytica, related Entamoeba, Giardia intestinalis and Trichomonas vaginalis. J Eukaryot Microbiol. 1995 May-Jun;42(3):277–278. doi: 10.1111/j.1550-7408.1995.tb01579.x. [DOI] [PubMed] [Google Scholar]
  27. Eckmann L., Reed S. L., Smith J. R., Kagnoff M. F. Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha. J Clin Invest. 1995 Sep;96(3):1269–1279. doi: 10.1172/JCI118161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Edman U., Meza I., Agabian N. Genomic and cDNA actin sequences from a virulent strain of Entamoeba histolytica. Proc Natl Acad Sci U S A. 1987 May;84(9):3024–3028. doi: 10.1073/pnas.84.9.3024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Espinosa-Cantellano M., Martínez-Palomo A. Entamoeba histolytica: mechanism of surface receptor capping. Exp Parasitol. 1994 Nov;79(3):424–435. doi: 10.1006/expr.1994.1104. [DOI] [PubMed] [Google Scholar]
  30. Flores-Romo L., Tsutsumi V., Estrada-García T., Shibayama M., Aubry J. P., Bacon K. B., Martínez-Palomo A. CD59 (protectin) molecule, resistance to complement, and virulence of Entamoeba histolytica. Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):116–117. doi: 10.1016/0035-9203(94)90530-4. [DOI] [PubMed] [Google Scholar]
  31. Gadasi H., Kessler E. Correlation of virulence and collagenolytic activity in Entamoeba histolytica. Infect Immun. 1983 Feb;39(2):528–531. doi: 10.1128/iai.39.2.528-531.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Gadasi H., Kobiler D. Entamoeba histolytica: correlation between virulence and content of proteolytic enzymes. Exp Parasitol. 1983 Feb;55(1):105–110. doi: 10.1016/0014-4894(83)90003-6. [DOI] [PubMed] [Google Scholar]
  33. Gathiram V., Jackson T. F. A longitudinal study of asymptomatic carriers of pathogenic zymodemes of Entamoeba histolytica. S Afr Med J. 1987 Nov 21;72(10):669–672. [PubMed] [Google Scholar]
  34. Gögler H., Knight R. The effect of hepatic injury upon the development of amoebic liver abscess in hamsters. Ann Trop Med Parasitol. 1974 Jun;68(2):177–185. doi: 10.1080/00034983.1974.11686936. [DOI] [PubMed] [Google Scholar]
  35. Hamelmann C., Foerster B., Burchard G. D., Horstmann R. D. Lysis of pathogenic and nonpathogenic Entamoeba histolytica by human complement: methodological analysis. Parasite Immunol. 1992 Jan;14(1):23–35. doi: 10.1111/j.1365-3024.1992.tb00003.x. [DOI] [PubMed] [Google Scholar]
  36. Hamelmann C., Foerster B., Burchard G. D., Shetty N., Horstmann R. D. Induction of complement resistance in cloned pathogenic Entamoeba histolytica. Parasite Immunol. 1993 Apr;15(4):223–228. doi: 10.1111/j.1365-3024.1993.tb00604.x. [DOI] [PubMed] [Google Scholar]
  37. Hamelmann C., Urban B., Foerster B., Horstmann R. D. Complement resistance of pathogenic Entamoeba histolytica mediated by trypsin-sensitive surface component(s). Infect Immun. 1993 May;61(5):1636–1640. doi: 10.1128/iai.61.5.1636-1640.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Horstmann R. D., Leippe M., Tannich E. Recent progress in the molecular biology of Entamoeba histolytica. Trop Med Parasitol. 1992 Dec;43(4):213–218. [PubMed] [Google Scholar]
  39. Huber M., Garfinkel L., Gitler C., Mirelman D., Revel M., Rozenblatt S. Entamoeba histolytica: cloning and characterization of actin cDNA. Mol Biochem Parasitol. 1987 Jul;24(3):227–235. doi: 10.1016/0166-6851(87)90154-x. [DOI] [PubMed] [Google Scholar]
  40. Huber M., Koller B., Gitler C., Mirelman D., Revel M., Rozenblatt S., Garfinkel L. Entamoeba histolytica ribosomal RNA genes are carried on palindromic circular DNA molecules. Mol Biochem Parasitol. 1989 Jan 15;32(2-3):285–296. doi: 10.1016/0166-6851(89)90077-7. [DOI] [PubMed] [Google Scholar]
  41. Irusen E. M., Jackson T. F., Simjee A. E. Asymptomatic intestinal colonization by pathogenic Entamoeba histolytica in amebic liver abscess: prevalence, response to therapy, and pathogenic potential. Clin Infect Dis. 1992 Apr;14(4):889–893. doi: 10.1093/clinids/14.4.889. [DOI] [PubMed] [Google Scholar]
  42. Jackson T. F., Gathiram V., Simjee A. E. Seroepidemiological study of antibody responses to the zymodemes of Entamoeba histolytica. Lancet. 1985 Mar 30;1(8431):716–719. doi: 10.1016/s0140-6736(85)91262-0. [DOI] [PubMed] [Google Scholar]
  43. Jacobs T., Leippe M. Purification and molecular cloning of a major antibacterial protein of the protozoan parasite Entamoeba histolytica with lysozyme-like properties. Eur J Biochem. 1995 Aug 1;231(3):831–838. doi: 10.1111/j.1432-1033.1995.0831d.x. [DOI] [PubMed] [Google Scholar]
  44. Jansson A., Gillin F., Kagardt U., Hagblom P. Coding of hemolysins within the ribosomal RNA repeat on a plasmid in Entamoeba histolytica. Science. 1994 Mar 11;263(5152):1440–1443. doi: 10.1126/science.8128227. [DOI] [PubMed] [Google Scholar]
  45. Jarumilinta R., Maegraith B. G. Enzymes of entamoeba histolytica. Bull World Health Organ. 1969;41(2):269–273. [PMC free article] [PubMed] [Google Scholar]
  46. Keene W. E., Hidalgo M. E., Orozco E., McKerrow J. H. Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol. 1990 Aug;71(2):199–206. doi: 10.1016/0014-4894(90)90022-5. [DOI] [PubMed] [Google Scholar]
  47. Keene W. E., Petitt M. G., Allen S., McKerrow J. H. The major neutral proteinase of Entamoeba histolytica. J Exp Med. 1986 Mar 1;163(3):536–549. doi: 10.1084/jem.163.3.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Keller K., Olivier M., Chadee K. The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation. Arch Med Res. 1992;23(2):217–221. [PubMed] [Google Scholar]
  49. Kelsall B. L., Ravdin J. I. Amebiasis: human infection with Entamoeba histolytica. Prog Clin Parasitol. 1994;4:27–54. [PubMed] [Google Scholar]
  50. Kollaritsch H., Graf J., Stemberger H., Krumpolz B., Binder M., Scheiner O., Wiedermann G. Interaction of different strains of Entamoeba histolytica with target cells: characterization of electrophysiological and morphological features. Immunobiology. 1989 Jun;179(2-3):190–201. doi: 10.1016/S0171-2985(89)80016-6. [DOI] [PubMed] [Google Scholar]
  51. Leippe M. Ancient weapons: NK-lysin, is a mammalian homolog to pore-forming peptides of a protozoan parasite. Cell. 1995 Oct 6;83(1):17–18. doi: 10.1016/0092-8674(95)90229-5. [DOI] [PubMed] [Google Scholar]
  52. Leippe M., Andrä J., Nickel R., Tannich E., Müller-Eberhard H. J. Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes. Mol Microbiol. 1994 Dec;14(5):895–904. doi: 10.1111/j.1365-2958.1994.tb01325.x. [DOI] [PubMed] [Google Scholar]
  53. Leippe M., Bahr E., Tannich E., Horstmann R. D. Comparison of pore-forming peptides from pathogenic and nonpathogenic Entamoeba histolytica. Mol Biochem Parasitol. 1993 May;59(1):101–109. doi: 10.1016/0166-6851(93)90011-l. [DOI] [PubMed] [Google Scholar]
  54. Leippe M., Ebel S., Schoenberger O. L., Horstmann R. D., Müller-Eberhard H. J. Pore-forming peptide of pathogenic Entamoeba histolytica. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7659–7663. doi: 10.1073/pnas.88.17.7659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Leippe M., Müller-Eberhard H. J. The pore-forming peptide of Entamoeba histolytica, the protozoan parasite causing human amoebiasis. Toxicology. 1994 Feb 28;87(1-3):5–18. doi: 10.1016/0300-483x(94)90151-1. [DOI] [PubMed] [Google Scholar]
  56. Leippe M., Sievertsen H. J., Tannich E., Horstmann R. D. Spontaneous release of cysteine proteinases but not of pore-forming peptides by viable Entamoeba histolytica. Parasitology. 1995 Dec;111(Pt 5):569–574. doi: 10.1017/s0031182000077040. [DOI] [PubMed] [Google Scholar]
  57. Leroy A., De Bruyne G., Mareel M., Nokkaew C., Bailey G., Nelis H. Contact-dependent transfer of the galactose-specific lectin of Entamoeba histolytica to the lateral surface of enterocytes in culture. Infect Immun. 1995 Nov;63(11):4253–4260. doi: 10.1128/iai.63.11.4253-4260.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Leroy A., Mareel M., De Bruyne G., Bailey G., Nelis H. Metastasis of Entamoeba histolytica compared to colon cancer: one more step in invasion. Invasion Metastasis. 1994;14(1-6):177–191. [PubMed] [Google Scholar]
  59. Long-Krug S. A., Fischer K. J., Hysmith R. M., Ravdin J. I. Phospholipase A enzymes of Entamoeba histolytica: description and subcellular localization. J Infect Dis. 1985 Sep;152(3):536–541. doi: 10.1093/infdis/152.3.536. [DOI] [PubMed] [Google Scholar]
  60. Lushbaugh W. B., Hofbauer A. F., Kairalla A. A., Cantey J. R., Pittman F. E. Relationship of cytotoxins of axenically cultivated Entamoeba histolytica to virulence. Gastroenterology. 1984 Jun;86(6):1488–1495. [PubMed] [Google Scholar]
  61. Lynch E. C., Rosenberg I. M., Gitler C. An ion-channel forming protein produced by Entamoeba histolytica. EMBO J. 1982;1(7):801–804. doi: 10.1002/j.1460-2075.1982.tb01250.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. López-Revilla R., Said-Fernández S. Cytopathogenicity of Entamoeba histolytica: hemolytic activity of trophozoite homogenates. Am J Trop Med Hyg. 1980 Mar;29(2):209–212. doi: 10.4269/ajtmh.1980.29.209. [DOI] [PubMed] [Google Scholar]
  63. Mann B. J., Torian B. E., Vedvick T. S., Petri W. A., Jr Sequence of a cysteine-rich galactose-specific lectin of Entamoeba histolytica. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3248–3252. doi: 10.1073/pnas.88.8.3248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Martinez-Palomo A., Gonzalez-Robles A., De la Torre M. Selective agglutination of pathogenic strains of Entamoeba histolytica induced con A. Nat New Biol. 1973 Oct 10;245(145):186–187. doi: 10.1038/newbio245186a0. [DOI] [PubMed] [Google Scholar]
  65. McLaughlin J., Faubert G. Partial purification and some properties of a neutral sulfhydryl and an acid proteinase from Entamoeba histolytica. Can J Microbiol. 1977 Apr;23(4):420–425. doi: 10.1139/m77-062. [DOI] [PubMed] [Google Scholar]
  66. Meza I., Cázares F., Rosales-Encina J. L., Talamás-Rohana P., Rojkind M. Use of antibodies to characterize a 220-kilodalton surface protein from Entamoeba histolytica. J Infect Dis. 1987 Nov;156(5):798–805. doi: 10.1093/infdis/156.5.798. [DOI] [PubMed] [Google Scholar]
  67. Montfort I., Olivos A., Pérez-Tamayo R. Phagocytosis and proteinase activity are not related to pathogenicity of E. histolytica. Parasitol Res. 1993;79(2):160–162. doi: 10.1007/BF00932263. [DOI] [PubMed] [Google Scholar]
  68. Montfort I., Pérez-Tamayo R. Is phagocytosis related to virulence in Entamoeba histolytica Schaudinn, 1903? Parasitol Today. 1994 Jul;10(7):271–273. doi: 10.1016/0169-4758(94)90144-9. [DOI] [PubMed] [Google Scholar]
  69. Mukherjee R. M., Mazumdar M., Maitra T. K., Jalan K. N. Virulence of nonpathogenic zymodemes of Entamoeba histolytica isolates from asymptomatic subjects in Calcutta, India. Braz J Med Biol Res. 1992;25(9):899–903. [PubMed] [Google Scholar]
  70. Muñoz M. L., Lamoyi E., León G., Tovar R., Pérez-García J., De La Torre M., Murueta E., Bernal R. M. Antigens in electron-dense granules from Entamoeba histolytica as possible markers for pathogenicity. J Clin Microbiol. 1990 Nov;28(11):2418–2424. doi: 10.1128/jcm.28.11.2418-2424.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Muńoz M. L., Calderón J., Rojkind M. The collagenase of Entamoeba histolytica. J Exp Med. 1982 Jan 1;155(1):42–51. doi: 10.1084/jem.155.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. NEAL R. A. Enzymic proteolysis by Entamoeba histolytica; biochemical characteristics and relationship with invasiveness. Parasitology. 1960 Nov;50:531–550. doi: 10.1017/s0031182000025610. [DOI] [PubMed] [Google Scholar]
  73. Orozco E., Benitez-Bibriesca L., Hernandez R. Invasion and metastasis mechanisms in Entamoeba histolytica and cancer cells. Some common cellular and molecular features. Mutat Res. 1994 Mar 1;305(2):229–239. doi: 10.1016/0027-5107(94)90243-7. [DOI] [PubMed] [Google Scholar]
  74. Orozco E., Guarneros G., Martinez-Palomo A., Sánchez T. Entamoeba histolytica. Phagocytosis as a virulence factor. J Exp Med. 1983 Nov 1;158(5):1511–1521. doi: 10.1084/jem.158.5.1511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Orozco E., Rodriquez M. A., Murphy C. F., Salata R. A., Petri W. A., Smith R. D., Ravdin J. I. Entamoeba histolytica: cytopathogenicity and lectin activity of avirulent mutants. Exp Parasitol. 1987 Apr;63(2):157–165. doi: 10.1016/0014-4894(87)90157-3. [DOI] [PubMed] [Google Scholar]
  76. Perez-Montfort R., Ostoa-Saloma P., Velazquez-Medina L., Montfort I., Becker I. Catalytic classes of proteinases of Entamoeba histolytica. Mol Biochem Parasitol. 1987 Nov;26(1-2):87–97. doi: 10.1016/0166-6851(87)90133-2. [DOI] [PubMed] [Google Scholar]
  77. Petri W. A., Jr, Jackson T. F., Gathiram V., Kress K., Saffer L. D., Snodgrass T. L., Chapman M. D., Keren Z., Mirelman D. Pathogenic and nonpathogenic strains of Entamoeba histolytica can be differentiated by monoclonal antibodies to the galactose-specific adherence lectin. Infect Immun. 1990 Jun;58(6):1802–1806. doi: 10.1128/iai.58.6.1802-1806.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Petri W. A., Jr, Snodgrass T. L., Jackson T. F., Gathiram V., Simjee A. E., Chadee K., Chapman M. D. Monoclonal antibodies directed against the galactose-binding lectin of Entamoeba histolytica enhance adherence. J Immunol. 1990 Jun 15;144(12):4803–4809. [PubMed] [Google Scholar]
  79. Prasad R., Tola M., Bhattacharya S., Sharma M. P., Bhattacharya A. Recognition of Entamoeba histolytica lipophosphoglycan by a strain-specific monoclonal antibody and human immune sera. Mol Biochem Parasitol. 1992 Dec;56(2):279–287. doi: 10.1016/0166-6851(92)90177-l. [DOI] [PubMed] [Google Scholar]
  80. Ragland B. D., Ashley L. S., Vaux D. L., Petri W. A., Jr Entamoeba histolytica: target cells killed by trophozoites undergo DNA fragmentation which is not blocked by Bcl-2. Exp Parasitol. 1994 Nov;79(3):460–467. doi: 10.1006/expr.1994.1107. [DOI] [PubMed] [Google Scholar]
  81. Rahim Z., Raymond-Denise A., Sansonetti P., Guillen N. Localization of myosin heavy chain A in the human pathogen Entamoeba histolytica. Infect Immun. 1993 Mar;61(3):1048–1054. doi: 10.1128/iai.61.3.1048-1054.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Ramakrishnan G., Ragland B. D., Purdy J. E., Mann B. J. Physical mapping and expression of gene families encoding the N-acetyl D-galactosamine adherence lectin of Entamoeba histolytica. Mol Microbiol. 1996 Jan;19(1):91–100. doi: 10.1046/j.1365-2958.1996.356885.x. [DOI] [PubMed] [Google Scholar]
  83. Ravdin J. I. Amebiasis. Clin Infect Dis. 1995 Jun;20(6):1453–1466. doi: 10.1093/clinids/20.6.1453. [DOI] [PubMed] [Google Scholar]
  84. Ravdin J. I., Croft B. Y., Guerrant R. L. Cytopathogenic mechanisms of Entamoeba histolytica. J Exp Med. 1980 Aug 1;152(2):377–390. doi: 10.1084/jem.152.2.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Ravdin J. I., Guerrant R. L. Role of adherence in cytopathogenic mechanisms of Entamoeba histolytica. Study with mammalian tissue culture cells and human erythrocytes. J Clin Invest. 1981 Nov;68(5):1305–1313. doi: 10.1172/JCI110377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  86. Ravdin J. I., Moreau F., Sullivan J. A., Petri W. A., Jr, Mandell G. L. Relationship of free intracellular calcium to the cytolytic activity of Entamoeba histolytica. Infect Immun. 1988 Jun;56(6):1505–1512. doi: 10.1128/iai.56.6.1505-1512.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Ravdin J. I., Murphy C. F., Guerrant R. L., Long-Krug S. A. Effect of antagonists of calcium and phospholipase A on the cytopathogenicity of Entamoeba histolytica. J Infect Dis. 1985 Sep;152(3):542–549. doi: 10.1093/infdis/152.3.542. [DOI] [PubMed] [Google Scholar]
  88. Raymond-Denise A., Sansonetti P., Guillén N. Identification and characterization of a myosin heavy chain gene (mhcA) from the human parasitic pathogen Entamoeba histolytica. Mol Biochem Parasitol. 1993 May;59(1):123–131. doi: 10.1016/0166-6851(93)90013-n. [DOI] [PubMed] [Google Scholar]
  89. Reed S. L., Gigli I. Lysis of complement-sensitive Entamoeba histolytica by activated terminal complement components. Initiation of complement activation by an extracellular neutral cysteine proteinase. J Clin Invest. 1990 Dec;86(6):1815–1822. doi: 10.1172/JCI114911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Reed S. L., Keene W. E., McKerrow J. H. Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol. 1989 Dec;27(12):2772–2777. doi: 10.1128/jcm.27.12.2772-2777.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Reed S. L., Sargeaunt P. G., Braude A. I. Resistance to lysis by human serum of pathogenic Entamoeba histolytica. Trans R Soc Trop Med Hyg. 1983;77(2):248–253. doi: 10.1016/0035-9203(83)90083-4. [DOI] [PubMed] [Google Scholar]
  92. Reed S., Bouvier J., Pollack A. S., Engel J. C., Brown M., Hirata K., Que X., Eakin A., Hagblom P., Gillin F. Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. J Clin Invest. 1993 Apr;91(4):1532–1540. doi: 10.1172/JCI116359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Rigothier M. C., García-Rivera G., Guaderrama M., Orozco E. Purification and functional characterization of the 112 kDa adhesin of Entamoeba histolytica. Arch Med Res. 1992;23(2):239–241. [PubMed] [Google Scholar]
  94. Rosales-Encina J. L., Meza I., López-De-León A., Talamás-Rohana P., Rojkind M. Isolation of a 220-kilodalton protein with lectin properties from a virulent strain of Entamoeba histolytica. J Infect Dis. 1987 Nov;156(5):790–797. doi: 10.1093/infdis/156.5.790. [DOI] [PubMed] [Google Scholar]
  95. Rosales-Encina J. L., Schlie-Guzmán M. A., Jiménez-Delgadillo B., Talamás-Rohana P., Matluk M. R. Purification and partial characterization of an hemolytic activity from Entamoeba histolytica. Arch Med Res. 1992;23(2):243–248. [PubMed] [Google Scholar]
  96. Rosenberg I., Bach D., Loew L. M., Gitler C. Isolation, characterization and partial purification of a transferable membrane channel (amoebapore) produced by Entamoeba histolytica. Mol Biochem Parasitol. 1989 Mar 15;33(3):237–247. doi: 10.1016/0166-6851(89)90085-6. [DOI] [PubMed] [Google Scholar]
  97. Said-Fernández S., López-Revilla R. Free fatty acids released from phospholipids are the major heat-stable hemolytic factor of Entamoeba histolytica trophozoites. Infect Immun. 1988 Apr;56(4):874–879. doi: 10.1128/iai.56.4.874-879.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  98. Said-Fernández S., López-Revilla R. Subcellular distribution and stability of the major hemolytic activity of Entamoeba histolytica trophozoites. Z Parasitenkd. 1982;67(3):249–254. doi: 10.1007/BF00927659. [DOI] [PubMed] [Google Scholar]
  99. Santiago A., Carbajal M. E., Benítez-King G., Meza I. Entamoeba histolytica: PKC transduction pathway activation in the trophozoite-fibronectin interaction. Exp Parasitol. 1994 Nov;79(3):436–444. doi: 10.1006/expr.1994.1105. [DOI] [PubMed] [Google Scholar]
  100. Scholze H., Tannich E. Cysteine endopeptidases of Entamoeba histolytica. Methods Enzymol. 1994;244:512–523. doi: 10.1016/0076-6879(94)44037-9. [DOI] [PubMed] [Google Scholar]
  101. Scholze H., Werries E. A weakly acidic protease has a powerful proteolytic activity in Entamoeba histolytica. Mol Biochem Parasitol. 1984 Apr;11:293–300. doi: 10.1016/0166-6851(84)90073-2. [DOI] [PubMed] [Google Scholar]
  102. Schulte W., Scholze H. Action of the major protease from Entamoeba histolytica on proteins of the extracellular matrix. J Protozool. 1989 Nov-Dec;36(6):538–543. doi: 10.1111/j.1550-7408.1989.tb01092.x. [DOI] [PubMed] [Google Scholar]
  103. Serrano J. J., de la Garza M., Moreno M. A., Tovar R., León G., Tsutsumi V., Muñoz M. L. Entamoeba histolytica: electron-dense granule secretion, collagenase activity and virulence are altered in the cytoskeleton mutant BG-3. Mol Microbiol. 1994 Feb;11(4):787–792. doi: 10.1111/j.1365-2958.1994.tb00356.x. [DOI] [PubMed] [Google Scholar]
  104. Spice W. M., Ackers J. P. Influence of bacteria on electrophoretic proteinase patterns of Entamoeba histolytica isolates. Int J Parasitol. 1993 Aug;23(5):671–674. doi: 10.1016/0020-7519(93)90176-y. [DOI] [PubMed] [Google Scholar]
  105. Spice W. M., Ackers J. P. The effect of axenic versus xenic culture conditions on the total and secreted proteolytic activity of Entamoeba histolytica strains. Arch Med Res. 1992;23(2):91–93. [PubMed] [Google Scholar]
  106. Stanley S. L., Jr, Huizenga H., Li E. Isolation and partial characterization of a surface glycoconjugate of Entamoeba histolytica. Mol Biochem Parasitol. 1992 Jan;50(1):127–138. doi: 10.1016/0166-6851(92)90250-n. [DOI] [PubMed] [Google Scholar]
  107. Stanley S. L., Jr, Zhang T., Rubin D., Li E. Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice. Infect Immun. 1995 Apr;63(4):1587–1590. doi: 10.1128/iai.63.4.1587-1590.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Talamás-Rohana P., Meza I. Interaction between pathogenic amebas and fibronectin: substrate degradation and changes in cytoskeleton organization. J Cell Biol. 1988 May;106(5):1787–1794. doi: 10.1083/jcb.106.5.1787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Tannich E., Ebert F., Horstmann R. D. Primary structure of the 170-kDa surface lectin of pathogenic Entamoeba histolytica. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1849–1853. doi: 10.1073/pnas.88.5.1849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Tannich E., Scholze H., Nickel R., Horstmann R. D. Homologous cysteine proteinases of pathogenic and nonpathogenic Entamoeba histolytica. Differences in structure and expression. J Biol Chem. 1991 Mar 15;266(8):4798–4803. [PubMed] [Google Scholar]
  111. Trissl D., Martínez-Palomo A., de la Torre M., de la Hoz R., Pérez de Suárez E. Surface properties of Entamoeba: increased rates of human erythrocyte phagocytosis in pathogenic strains. J Exp Med. 1978 Nov 1;148(5):1137–1143. doi: 10.1084/jem.148.5.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Tsutsumi V., Ramírez-Rosales A., Lanz-Mendoza H., Shibayama M., Chávez B., Rangel-López E., Martínez-Palomo A. Entamoeba histolytica: erythrophagocytosis, collagenolysis, and liver abscess production as virulence markers. Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):170–172. doi: 10.1016/0035-9203(92)90555-q. [DOI] [PubMed] [Google Scholar]
  113. Upcroft J. A., Healey A., Mitchell R., Boreham P. F., Upcroft P. Antigen expression from the ribosomal DNA repeat unit of Giardia intestinalis. Nucleic Acids Res. 1990 Dec 11;18(23):7077–7081. doi: 10.1093/nar/18.23.7077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  114. Vargas-Villarreal J., Martínez-Rodríguez H., Castro-Garza J., Mata-Cárdenas B. D., González-Garza M. T., Said-Fernández S. Identification of Entamoeba histolytica intracellular phospholipase A and lysophospholipase L1 activities. Parasitol Res. 1995;81(4):320–323. doi: 10.1007/BF00931538. [DOI] [PubMed] [Google Scholar]
  115. Vargas M. A., Isibasi A., Kumate J., Orozco E. Non-pathogenic Entamoeba histolytica: functional and biochemical characterization of a monoxenic strain. Mol Biochem Parasitol. 1990 May;40(2):193–201. doi: 10.1016/0166-6851(90)90041-j. [DOI] [PubMed] [Google Scholar]
  116. Vázquez-Prado J., Meza I. Fibronectin "receptor" in Entamoeba histolytica: purification and association with the cytoskeleton. Arch Med Res. 1992;23(2):125–128. [PubMed] [Google Scholar]
  117. Vázquez J., Franco E., Reyes G., Meza I. Characterization of adhesion plates induced by the interaction of Entamoeba histolytica trophozoites with fibronectin. Cell Motil Cytoskeleton. 1995;32(1):37–45. doi: 10.1002/cm.970320105. [DOI] [PubMed] [Google Scholar]
  118. Walsh J. A. Problems in recognition and diagnosis of amebiasis: estimation of the global magnitude of morbidity and mortality. Rev Infect Dis. 1986 Mar-Apr;8(2):228–238. doi: 10.1093/clinids/8.2.228. [DOI] [PubMed] [Google Scholar]
  119. Weikel C. S., Murphy C. F., Orozco E., Ravdin J. I. Phorbol esters specifically enhance the cytolytic activity of Entamoeba histolytica. Infect Immun. 1988 Jun;56(6):1485–1491. doi: 10.1128/iai.56.6.1485-1491.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  120. Young J. D., Cohn Z. A. Molecular mechanisms of cytotoxicity mediated by Entamoeba histolytica: characterization of a pore-forming protein (PFP). J Cell Biochem. 1985;29(4):299–308. doi: 10.1002/jcb.240290404. [DOI] [PubMed] [Google Scholar]
  121. Young J. D., Young T. M., Lu L. P., Unkeless J. C., Cohn Z. A. Characterization of a membrane pore-forming protein from Entamoeba histolytica. J Exp Med. 1982 Dec 1;156(6):1677–1690. doi: 10.1084/jem.156.6.1677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. de Meester F., Shaw E., Scholze H., Stolarsky T., Mirelman D. Specific labeling of cysteine proteinases in pathogenic and nonpathogenic Entamoeba histolytica. Infect Immun. 1990 May;58(5):1396–1401. doi: 10.1128/iai.58.5.1396-1401.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

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