Thyrotropin (TSH), free thyroxine (FT4), and total thyroxine (TT4) in male versus female recombinant inbred mice (strains BXH, CXB, and AXBXA). Box plots indicate the median, 25th, and 75th percentiles and, as error bars, the 10th and 90th percentiles; “outliers” are shown as open circles. The numbers of strains investigated is given in parentheses. FT4 and TT4 data for female mice from references (12–14) and for TSH from (17). Values significantly different between males and females: TSH, **p<0.001 (paired t-test); *p<0.001 (signed-rank test); FT4, ^p=0.018 (t-test); *p=0.009 and **p<0.001 (paired t-tests); TT4: **p=0.003 (paired t-test); *p<0.001 (signed-rank test).