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. 2014 Jun 10;142(3):414–420. doi: 10.1111/imm.12266

Figure 3.

Figure 3

Lipopolysaccharide (LPS) lethality in sex-matched and age-matched Crp knockout and control wild-type C57BL/6 mice. There was no significant difference between survival of mice in the two groups after administration of LPS at 10 mg/kg (a), 20 mg/kg (b) or 40 mg/kg (c). The apparent trend to greater susceptibility in the Crp knockout mice receiving 40 mg/kg, which did not achieve statistical significance, is well within the typical variation in outcome after administration of LPS to mice. Biological significance is not supported by the fact that the knockouts were not more susceptible than wild-type mice to smaller doses of LPS.