Effects of RSLE on insulin sensitivity and glucose metabolism. DIO mice were treated with vehicle (water), RSLE, or Metformin for 28 days. After 21 days of treatment mice were given an insulin tolerance test (A & B). After 25 days of treatment, mice were given an oral glucose tolerance test (C & D). Data are presented as (A & C) mean blood glucose ± SE and (B & D) area under the curve ± SE (n = 10, except Metformin, n = 5; *p < 0.05; **p < 0.01, ***p < 0.001).