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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Glia. 2014 Mar 26;62(7):1093–1109. doi: 10.1002/glia.22665

Figure 3. Endogenous IL-1β in the spinal dorsal horn of neuropathic mice reduces glial glutamate transporter activities.

Figure 3

(A) shows samples of GTCs recorded from sham-operated and neuropathic mice and the mean (+S.E.) amplitude and charge transfer of GTCs in both sham and neuropathic (NP) mice. (B) Samples of GTCs recorded from neuropathic mice before (baseline), during and after washout of the IL-1β inhibitor (IL-1ra, 100 ng/ml) are shown. (C) Samples of GTCs recorded from sham-operated mice before and during perfusion of IL-1ra (100 ng/ml) are shown. (D) Samples of GTCs recorded from sham-operated mice before, during and after washout of IL-1β (10 ng/ml) are shown. The measurements of GTC amplitudes for each cell over time are plotted. Bar graphs show the mean (+S.E.) amplitude of GTCs before (baseline), during and after washout of each tested agent. *** p<0.001; NS: no statistical significance.