In this article (Cancer Epidemiol Biomarkers Prev 2013;22:681-687) which was published in the April 2013 issue of Cancer Epidemiology, Biomarkers & Prevention (1), the column in Table 2 with the number of samples for the ≥75 year age group was erroneously moved into the p-value column for the <75 year age group and all subsequent columns were shifted to the left due to a production error. The correct version of the table appears below. The publisher regrets the error.
Table 2.
< 75 years old | ≥ 75 years old |
p
for interactionc |
|||||||
---|---|---|---|---|---|---|---|---|---|
|
|||||||||
Cases | Person- years |
HR (95%CI)b | p or ptrend | Cases | Person- years |
HR (95%CI) b | p or ptrend | ||
Ovarian Cancer | |||||||||
Age at baseline | |||||||||
< 60 | 92 | 159,819 | 1.0 | 21 | 43,137 | 1.0 | |||
60 – 64 | 58 | 119,523 | 0.87 (0.61 – 1.25) | 46 | 78,298 | 1.31 (0.75 – 2.27) | |||
≥ 65 | 37 | 62,017 | 1.20 (0.77 – 1.87) | 0.64 | 68 | 93,486 | 1.68 (0.98 – 2.88) | 0.047 | 0.30 |
Physical activity level | |||||||||
Low | 71 | 159,835 | 1.0 | 57 | 42,905 | 1.0 | |||
Moderate | 53 | 91,546 | 1.27 (0.88 – 1.83) | 44 | 88,953 | 1.23 (0.82 – 1.85) | |||
High | 58 | 83,840 | 1.55 (1.08 – 2.22) | 0.02 | 30 | 83,063 | 0.97 (0.62 – 1.53) | 0.97 | 0.12 |
Family history of
ovarian cancerd |
|||||||||
No | 173 | 332,244 | 1.0 | 132 | 209,471 | 1.0 | |||
Yes | 14 | 9,118 | 3.16 (1.83 – 5.45) | <0.0001 | 3 | 5,450 | 0.93 (0.30 – 2.93) | 0.90 | 0.06 |
Number of live births | |||||||||
0 | 23 | 27,255 | 1.0 | 13 | 19,697 | 1.0 | |||
1 – 2 | 59 | 101,834 | 0.69 (0.42 – 1.13) | 41 | 70,019 | 0.91 (0.48 – 1.74) | |||
3 – 4 | 74 | 138,568 | 0.60 (0.37 – 0.96) | 59 | 83,250 | 1.13 (0.60 – 2.11) | |||
5+ | 31 | 71,782 | 0.45 (0.25 – 0.79) | 0.005 | 21 | 40,477 | 0.85 (0.41 – 1.74) | 0.98 | 0.09 |
Colon Cancer | |||||||||
Age at baseline | |||||||||
<60 | 236 | 201,656 | 1.0 | 109 | 56,755 | 1.0 | |||
60 – 64 | 228 | 147,680 | 1.57 (1.29 – 1.92) | 281 | 99,470 | 1.29 (1.02 – 1.64) | |||
≥65 | 140 | 74,351 | 2.28 (1.78 – 2.92) | <0.0001 | 317 | 115,039 | 1.26 (0.99 – 1.60) | 0.14 | 0.0002 |
Body mass index (BMI) | |||||||||
<25 | 198 | 167,647 | 1.0 | 244 | 106,267 | 1.0 | |||
25 - <30 | 235 | 156,583 | 1.28 (1.06 – 1.56) | 274 | 103,759 | 1.18 (0.99 – 1.41) | |||
≥30 | 171 | 99,157 | 1.44 (1.16 – 1.78) | 0.0006 | 189 | 61,237 | 1.38 (1.13 – 1.69) | 0.001 | 0.69 |
Smoking | |||||||||
Never | 370 | 274,486 | 1.0 | 495 | 191,764 | 1.0 | |||
Past | 130 | 80,119 | 1.27 (1.04 – 1.56) | 115 | 47,178 | 0.97 (0.79 – 119) | |||
Current | 96 | 62,381 | 1.27 (1.01 – 1.60) | 0.01 | 79 | 27,915 | 1.22 (0.96 – 1.56) | 0.22 | 0.53 |
Estrogen use | |||||||||
Never | 419 | 262,588 | 1.0 | 454 | 166,168 | 1.0 | |||
Ever | 185 | 160,799 | 0.71 (0.60 – 0.85) | 0.0002 | 253 | 105,196 | 0.88 (0.75 – 1.03) | 0.11 | 0.10 |
History of diabetes | |||||||||
No | 553 | 399,956 | 1.0 | 655 | 258,939 | 1.0 | |||
Yes | 51 | 22,877 | 1.35 (0.99 – 1.84) | 0.06 | 51 | 11,928 | 1.59 (1.18 – 2.14) | 0.002 | 0.54 |
Aspirin or NSAID usee | |||||||||
No | 100 | 60,565 | 1.0 | 125 | 40,488 | 1.0 | |||
Yes | 320 | 288,148 | 0.70 (0.56 – 0.89) | 0.003 | 460 | 188,029 | 0.78 (0.64 – 0.95) | 0.02 | 0.45 |
Rectal Cancer | |||||||||
Age at baseline | |||||||||
<60 | 73 | 202,603 | 1.0 | 23 | 57,570 | 1.0 | |||
60 – 64 | 65 | 147,866 | 1.40 (0.97 – 2.01) | 48 | 101,157 | 1.11 (0.66 – 1.89) | |||
≥65 | 45 | 74,575 | 2.34 (1.51 – 3.63) | 0.0002 | 61 | 117,037 | 1.18 (0.69 – 2.00) | 0.56 | 0.05 |
Smoking | |||||||||
Never | 105 | 275,540 | 1.0 | 90 | 194,832 | 1.0 | |||
Past | 38 | 80,560 | 1.23 (0.84 – 1.80) | 26 | 48,062 | 1.23 (0.80 – 1.91) | |||
Current | 35 | 62,541 | 1.68 (1.13 – 2.49) | 0.01 | 14 | 28,401 | 1.19 (0.67 – 2.11) | 0.36 | 0.54 |
Estrogen use | |||||||||
Never | 129 | 263,669 | 1.0 | 87 | 169,110 | 1.0 | |||
Ever | 54 | 161,375 | 0.70 (0.50 – 0.96) | 0.03 | 45 | 106,654 | 1.00 (0.67 – 1.48) | 1.00 | 0.37 |
Oral contraceptive use | |||||||||
No | 140 | 332,079 | 1.0 | 122 | 234,829 | 1.0 | |||
Yes | 43 | 92,964 | 1.27 (0.88 – 1.83) | 0.20 | 10 | 40,935 | 0.46 (0.23 – 0.91) | 0.03 | 0.04 |
Breast Cancer | |||||||||
Age at baseline | |||||||||
< 60 | 687 | 196,272 | 1.0 | 207 | 53,319 | 1.0 | |||
60 – 64 | 613 | 143,414 | 1.35 (1.19 – 1.52) | 414 | 93,515 | 1.10 (0.92 – 1.32) | |||
≥ 65 | 293 | 72,946 | 1.35 (1.15 – 1.58) | <0.0001 | 450 | 110,055 | 1.07 (0.89 – 1.29) | 0.59 | 0.006 |
Body mass index (BMI) | |||||||||
< 25 | 547 | 163,218 | 1.0 | 353 | 100,980 | 1.0 | |||
25 - < 30 | 606 | 152,625 | 1.18 (1.04 – 1.33) | 449 | 98,029 | 1.30 (1.12 – 1.52) | 0.0006 | ||
≥ 30 | 440 | 96,579 | 1.35 (1.17 – 1.55) | <0.0001 | 269 | 57,880 | 1.35 (1.13 – 1.62) | 0.001 | 0.80 |
Waist-hip-ratio (WHR) | |||||||||
Q1 (0.335 – 0.777) | 383 | 110,216 | 1.0 | 246 | 63,163 | 1.0 | |||
Q2 (>0.777 – 0.832) | 367 | 104,033 | 0.97 (0.83 – 1.12) | 258 | 65,248 | 0.99 (0.82 – 1.18) | |||
Q3 (>0.832 – 0.892) | 388 | 100,772 | 1.01 (0.87 – 1.18) | 271 | 65,577 | 0.99 (0.82 – 1.19) | |||
Q4 (>0.892 – 2.836) | 448 | 95,813 | 1.18 (1.01 – 1.38) | 0.02 | 290 | 61,990 | 1.05 (0.87 – 1.28) | 0.63 | 0.26 |
Family history of breast cancerd |
|||||||||
No | 1,138 | 318,733 | 1.0 | 732 | 198,514 | 1.0 | |||
Yes | 455 | 93,899 | 1.35 (1.21 – 1.51) | <0.0001 | 339 | 58,374 | 1.57 (1.37 – 1.79) | <0.0001 | 0.09 |
Age at menarche | |||||||||
≤ 12 | 725 | 175,292 | 1.0 | 432 | 105,074 | 1.0 | |||
> 12 | 855 | 232,907 | 0.90 (0.81 – 1.00) | 0.048 | 631 | 148,502 | 1.06 (0.94 – 1.21) | 0.34 | 0.05 |
Age at menopause | |||||||||
< 50 | 778 | 215,226 | 1.0 | 463 | 130,677 | 1.0 | |||
≥ 50 | 815 | 197,407 | 1.15 (1.04 – 1.27) | 0.008 | 608 | 126,211 | 1.35 (1.19 – 1.53) | <0.0001 | 0.04 |
Number of live births | |||||||||
0 | 160 | 36,201 | 1.0 | 107 | 25,838 | 1.0 | |||
1 – 2 | 511 | 125,740 | 0.57 (0.39 – 0.84) | 384 | 84,903 | 0.70 (0.44 – 1.11) | |||
3 – 4 | 660 | 166,743 | 0.58 (0.41 – 0.82) | 409 | 98,813 | 0.64 (0.42 – 0.98) | |||
5+ | 262 | 83,948 | 0.45 (0.32 – 0.65) | <0.0001 | 171 | 47,335 | 0.57 (0.37 – 0.88) | 0.001 | 0.50 |
Age at first live birth | |||||||||
< 20 | 285 | 86,040 | 1.0 | 159 | 44,593 | 1.0 | |||
20 – 24 | 723 | 193,329 | 1.12 (0.98 – 1.29) | 463 | 112,881 | 1.18 (0.98 – 1.42) | |||
25 – 29 | 308 | 74,508 | 1.17 (0.99 – 1.39) | 247 | 55,451 | 1.18 (0.95 – 1.46) | |||
≥ 30 | 108 | 20,329 | 1.45 (1.14 – 1.83) | 0.003 | 89 | 16,613 | 1.40 (1.06 – 1.85) | 0.03 | 0.43 |
Nulliparous | 160 | 36,201 | 1.06 (0.84 – 1.34) | 107 | 25,838 | 1.05 (0.78 – 1.42) | |||
Smoking | |||||||||
Never | 998 | 267,781 | 1.0 | 744 | 181,870 | 1.0 | |||
Past | 313 | 78,153 | 1.06 (0.93 – 1.21) | 209 | 44,314 | 1.17 (1.00 – 1.38) | |||
Current | 265 | 60,483 | 1.25 (1.08 – 1.44) | 0.004 | 100 | 26,458 | 0.99 (0.80 – 1.24) | 0.43 | 0.22 |
Alcohol consumption | |||||||||
No | 832 | 228,828 | 1.0 | 631 | 149,329 | 1.0 | |||
Yes | 761 | 183,805 | 1.20 (1.08 – 1.33) | 0.0007 | 440 | 107,559 | 0.98 (0.86 – 1.11) | 0.73 | 0.02 |
History of hysterectomy | |||||||||
No | 1,088 | 276,458 | 1.0 | 703 | 174,329 | 1.0 | |||
Yes | 505 | 136,174 | 1.02 (0.91 – 1.16) | 0.71 | 368 | 82,530 | 1.31 (1.13 – 1.51) | 0.0003 | 0.03 |
Aspirin or NSAID usee | |||||||||
No | 256 | 56,990 | 1.0 | 159 | 36,932 | 1.0 | |||
Yes | 1,040 | 280,606 | 0.82 (0.71 – 0.94) | 0.005 | 737 | 177,556 | 0.94 (0.78 – 1.12) | 0.46 | 0.28 |
Includes only risk factors where the association was significant in at least one of the risk sets. All remaining risk factors are included in the supplementary tables.
Adjusted for age at baseline, BMI (kg/m2), physical activity level (low, moderate, high), smoking (never, past, current), age at menarche (ovarian, breast), estrogen use (colon, rectal), WHR (breast), age at menopause (breast), number of live births (breast), age at first live births (breast) and alcohol intake (breast).
P values for tests whether HRs differ by the follow-up (< 75 y.o. vs ≥ 75 y.o.)
Family history among first and second degree relatives.
Analysis was restricted to women who were alive and responded to the follow-up 3 (1992) questionnaire.
Reference
- 1.Poynter JN, Inoue-Choi M, Ross JA, Jacobs DR, Jr, Robien K. Reproductive, Lifestyle, and Anthropometric Risk Factors for Cancer in Elderly Women. Cancer Epidemiol Biomarkers Prev. 2013;22:681–687. doi: 10.1158/1055-9965.EPI-12-0966. [DOI] [PMC free article] [PubMed] [Google Scholar]