TO THE EDITOR
I read with a great interest the paper by Gonzalez-Roldan et al[1]. The authors reported on the pattern expression of TREM-1 during sepsis and major abdominal surgery as compared to healthy controls and concluded that TREM-1 expression increased on the surface of monocytes after surgery. Several points deserve consideration. First, no data related to TREM-1 expression on neutrophils is provided. Second, of the 7 surgical patients, only 4 had both pre- and post-surgery cytometry analysis. Among these 4 patients, 2 displayed a decrease of TREM-1 expression after surgery. Therefore, it seems quite hazardous, based on these data, to conclude that TREM-1 increases after major uncomplicated surgery, reflecting a systemic inflammatory response.
The other question that arose from this study is related to the determination of the TREM-1 splice variant (svTREM-1). First, it is still unknown whether this variant is translated or not[2]. Anyway, the soluble form of TREM-1 is not believed to be related to this variant[3]. The authors observed an increase of the svTREM-1 mRNA after surgery or during sepsis. By using the described primers, one could also expect to see a PCR product corresponding to the natural form of TREM-1[3]. Unfortunately, such a product is not reported. Finally, it is rather disappointing not to see any measurement of plasma sTREM-1 in these patients in order to better characterise the “inflammatory” patients and the septic ones[4].
Footnotes
S- Editor Wang J E- Editor Bi L
References
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