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. 1995 Oct 10;92(21):9820–9823. doi: 10.1073/pnas.92.21.9820

Two redundant systems maintain levels of resident proteins within the yeast endoplasmic reticulum.

C T Beh 1, M D Rose 1
PMCID: PMC40894  PMID: 7568225

Abstract

The Saccharomyces cerevisiae gene ERD2 is responsible for the retrieval of lumenal resident proteins of the endoplasmic reticulum (ER) lost to the next secretory compartment. Previous studies have suggested that the retrieval of proteins by ERD2 is not essential. Here, we find that ERD2-mediated retrieval is not an essential process only because, on its failure, a second inducible system acts to maintain levels of ER proteins. The second system is controlled by the ER membrane-bound kinase encoded by IRE1. We conclude that IRE1 and ERD2 together maintain normal concentrations of resident proteins within the ER.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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