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. 1995 Sep 26;92(20):9102–9106. doi: 10.1073/pnas.92.20.9102

Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex.

O Kisselev 1, A Pronin 1, M Ermolaeva 1, N Gautam 1
PMCID: PMC40932  PMID: 7568081

Abstract

Receptor-G protein interaction is characterized by cycles of association and dissociation. We present evidence which indicates that during receptor-G protein interaction, the C-terminal tail of the G protein gamma subunit, which is masked in the beta gamma complex, is exposed and establishes high-affinity contact with the receptor. This potential conformational switch provides a mechanism to regulate receptor-G protein coupling. This switch may also be significant for the role of the beta gamma complex in regulation of effector function.

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