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. 2014 Feb 13;3:44. [Version 1] doi: 10.12688/f1000research.3-44.v1

Figure 1. PsicquicGraph rendering of the proteins in the VEGF signaling pathway.

Figure 1.

The VEGF pathway is an essential regulator of vasculogenesis, as well as angiogenesis. In adults, it is up-regulated in a vast number of tumors. Solid tumors often build novel blood vessels and VEGF is one important regulator in that development. It is also a drug target in tumor medicine and several drugs directly target the VEGF receptor to block blood vessel formation in tumors. ( a) Default values were used to define the layout as well as other visualization options. ( b) A force-directed layout was used to render the graph and other visualization options such as node shape, node color and node label were customized.