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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Pain. 2014 May 17;155(8):1632–1648. doi: 10.1016/j.pain.2014.05.015

Table 1.

Path a: Regions correlated with stimulation temperature.1

Brain Region (Brodmann Areas) Coordinates (mm) # of voxels p<.001 Volume (mm) Max Z-score Mean Path a coeff. (std. err) Mean p-value Path a

x y z
Temperature-related increases
Bilateral cerebellum -14 -66 -34 6081 48648 15.13 0.9010 (0.17) 0.0000
Right temporal pole 48 -22 -36 6 48 5.86 0.0774 (0.03) 0.0026
Right insula, contiguous with bilateral thalamus, midbrain, right inferior frontal gyrus, right lateral PFC, right premotor cortex, right lateral OFC, right hippocampus 36 2 8 12180 97440 17.22 0.9217 (0.12) 0.0001
Right Inferior Frontal Gyrus p. Orbitalis, contiguous with right anterior insula and right VLPFC 26 14 -24 12 96 5.45 0.4488 (0.17) 0.0087
Left Middle Orbital Gyrus -26 38 -20 84 672 11.18 0.6833 (0.18) 0.0002
Left Middle Orbital Gyrus -22 58 -16 38 304 6.26 0.8102 (0.34) 0.0050
Right Middle Temporal Gyrus 58 -40 -10 43 344 8.87 0.4104 (0.12) 0.0006
Left Rolandic Operculum -46 -4 10 3654 29232 13.63 0.8228 (0.10) 0.0002
Left Calcarine Gyrus (BA17) 2 -84 0 416 3328 10.26 0.9811 (0.25) 0.0003
Right Calcarine Gyrus (BA17) 16 -102 -4 18 144 5.9 0.3819 (0.15) 0.0043
Cerebellar Vermis 4/5 2 -46 -2 106 848 13.82 1.2624 (0.42) 0.0000
Left Insula Lobe (OP2) -38 -18 14 54 432 12.09 0.4722 (0.13) 0.0001
Right Middle Cingulate Cortex (BA6) 6 6 44 5699 45592 19.94 0.8975 (0.12) 0.0002
Left Middle Frontal Gyrus -38 42 28 320 2560 10.1 0.7566 (0.17) 0.0016
Right Middle Frontal Gyrus 38 50 28 18 144 5.62 0.8758 (0.30) 0.0037
Left caudal cingulate -18 -28 34 55 440 8.06 0.4528 (0.13) 0.0003
Left Inferior Parietal Lobule (hIP2) -44 -42 36 6 48 6.27 0.3704 (0.15) 0.0019
Left Precuneus -6 -80 54 4 32 5.21 0.5817 (0.25) 0.0100
Left Superior Frontal Gyrus (BA6) -18 4 66 238 1904 12.39 0.2750 (0.07) 0.0000
Right Superior Parietal Lobule 24 -46 70 367 2936 13.42 0.2867 (0.07) 0.0001
Temperature-related decreases
Right Medial Temporal Pole 44 12 -42 30 240 6.62 -0.5364 (0.18) 0.0006
Left hippocampus, contiguous with parahippocampal gyrus left medial temporal lobe, left occipital cortex -34 -54 -8 7155 57240 10.95 -0.7752 (0.10) 0.0006
Right hippocampus, contiguous with parahippocampal gyrus and right occipital cortex 40 -64 2 5973 47784 11.59 -0.8269 (0.14) 0.0005
Right Medial Temporal Pole 54 14 -32 2 16 4.87 -0.6793 (0.27) 0.0084
Right Middle Temporal Gyrus 58 -8 -16 429 3432 10.36 -0.9178 (0.21) 0.0001
Right amygdala 14 2 -28 4 32 5.71 -0.4142 (0.14) 0.0016
Left Rectal Gyrus -6 14 -24 22 176 7.02 -0.3120 (0.09) 0.0005
Right Inferior Temporal Gyrus 66 -24 -26 3 24 5.02 -0.1715 (0.06) 0.0033
Left Superior Medial Gyrus -4 54 4 1634 13072 9.44 -0.9172 (0.20) 0.0047
Left Rectal Gyrus -8 24 -14 11 88 5.86 -0.4067 (0.14) 0.0034
Right Cerebelum IV-V 10 -56 -12 4 32 4.86 -0.5879 (0.22) 0.0075
Left Inferior Frontal Gyrus p. Orbitalis -54 24 -4 42 336 6.96 -0.7147 (0.23) 0.0013
Right Precuneus 2 -44 44 2458 19664 11.26 -0.7598 (0.13) 0.0001
Left Superior Frontal Gyrus -18 62 2 6 48 5.28 -0.4488 (0.17) 0.0078
Right Superior Temporal Gyrus 44 -28 4 33 264 7.57 -0.3953 (0.11) 0.0002
Right Calcarine Gyrus (BA18) 22 -58 8 13 104 6.52 -0.6114 (0.21) 0.0052
RightPrecentral Gyrus (BA1) 52 -14 46 1377 11016 10.94 -0.7646 (0.15) 0.0004
Left Postcentral Gyrus (BA3b) -40 -32 52 3869 30952 11.1 -0.7422 (0.13) 0.0014
Right Superior Frontal Gyrus 22 36 38 350 2800 9.41 -0.5574 (0.13) 0.0003
Left Middle Frontal Gyrus -40 10 50 122 976 7.41 -0.5397 (0.16) 0.0011
Left Middle Frontal Gyrus -26 24 46 138 1104 8.49 -0.8461 (0.25) 0.0009
1

NOTE: This table presents results from Path a of the multi-level mediation analysis presented as a path diagram in Figure 1. Mediation effect parametric mapping results are presented in Figure 3.

***

p < .001

**

p < .01

*

p < .05