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. 2014 Apr 23;39(9):2263–2271. doi: 10.1038/npp.2014.77

Figure 4.

Figure 4

Activation of CeA GABAA receptors inhibits hyperalgesia and morphine reward. (a) Time course of pain threshold changes after intraplantar injection of CFA in rats with CeA infusion of saline or muscimol (two-way ANOVA, time, F(20,200)=61.04, p<0.0001; muscimol, F(1,10)=72.77, p<0.0001; time × muscimol, F(20,200)=11.35, p<0.0001; n=6 each group). BL, baseline. (b) Preference behaviors after five sessions of morphine conditioning in naïve rats pretreated with CeA infusion of vehicle or muscimol (*preference comparison within group by paired t-test: vehicle, t(1,10)=5.596, p=0.0025; muscimol, t(1,10)=1.003, p=0.3621. #Comparison between groups by two-way ANOVA: time, F(1,10)=24.61, p=0.0006; muscimol, F(1,10)=0.7951, p=0.3935; time × muscimol, F(1,10)=13.61, p=0.0042; n=6 each group). (c, d) Schematic drawing depicting the position of cannula tips (dots) for muscimol microinfusions (c) and an image of brain slice showing the infusion site with a dye (d) within the CeA. Scale bars=0.5 mm (c) and 1 mm (d).