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. 2014 Jul 1;53(28):4510–4518. doi: 10.1021/bi500610r

Figure 2.

Figure 2

Duplex RNAs are allele-selective inhibitors of ATN-1 expression. Gels are Western analyses of ATN-1 protein levels. Graphs are based on triplicate determinations. (A) Sequences, IC50 values, and selectivities of duplex RNAs used for panels B–F. Only the strand complementary to ATN-1 mRNA is shown. Both strands of the duplex contain two DNA/T at the 3′ end. Mismatched bases that are relative to the CAG repeat region are shown in bold italics. (B–F) Gel and dose response graphs for duplex RNAs REP, P9, P9-15, P9-16, and PM4, respectively.