Table 4.
Moderate/severe symptoms at T1 in colorectal cancer patients
| % of moderate/severe symptoms
|
Multivariable logistic model
|
||||||
|---|---|---|---|---|---|---|---|
| ≥40 years old | ≤ 39 years old | Adjusted OR | LCI | UCI | |||
|
| |||||||
| N | % | N | % | ||||
| Symptom | |||||||
| pain | 121 | 18.06 | 10 | 27.03 | 1.90* | 1.09 | 3.32 |
| fatigue | 212 | 31.98 | 18 | 48.65* | 2.68** | 1.30 | 5.53 |
| nausea | 63 | 9.39 | 8 | 21.62* | 2.59* | 1.02 | 6.59 |
| disturbed sleep | 151 | 22.64 | 11 | 29.73 | 1.68 | 0.77 | 3.67 |
| distress | 113 | 16.82 | 14 | 37.84** | 3.63** | 1.58 | 8.32 |
| Shortness of breath | 74 | 11.01 | 7 | 18.92 | 2.42* | 1.05 | 5.58 |
| remembering | 94 | 13.97 | 10 | 27.03* | 2.47 | 0.94 | 6.46 |
| Lack of appetite | 113 | 16.87 | 9 | 24.32 | 1.50 | 0.51 | 4.39 |
| drowsiness | 146 | 21.66 | 16 | 43.24** | 3.05** | 1.44 | 6.42 |
| Dry mouth | 105 | 15.65 | 6 | 16.22 | 1.26 | 0.48 | 3.34 |
| sad | 91 | 13.56 | 9 | 24.32 | 2.17 | 0.83 | 5.67 |
| vomiting | 22 | 3.27 | 3 | 8.11 | 2.00 | 0.38 | 10.64 |
| numbness | 171 | 25.45 | 12 | 32.43 | 1.37 | 0.60 | 3.15 |
| diarrhea | 106 | 15.77 | 6 | 16.22 | 1.49 | 0.56 | 3.94 |
| constipation | 73 | 10.88 | 5 | 13.51 | 1.32 | 0.51 | 3.38 |
| Sore mouth | 41 | 6.10 | 2 | 5.41 | 0.82 | 0.23 | 2.96 |
| rash | 63 | 9.43 | 6 | 16.22 | 2.80* | 1.00 | 7.84 |
| Hair loss | 71 | 10.61 | 4 | 10.81 | 0.65 | 0.15 | 2.78 |
| coughing | 41 | 6.10 | 4 | 10.81 | 2.53 | 0.71 | 8.99 |
|
| |||||||
| Symptom Interference | |||||||
| General activity | 146 | 21.73 | 16 | 43.24** | 3.01** | 1.56 | 5.79 |
| Mood | 103 | 15.30 | 15 | 40.54** | 3.80** | 2.02 | 7.12 |
| Work | 150 | 22.35 | 15 | 40.54* | 2.57** | 1.39 | 4.74 |
| Relations | 74 | 11.03 | 9 | 24.32* | 3.04* | 1.14 | 8.11 |
| Walking | 150 | 22.32 | 10 | 27.03 | 1.52 | 0.74 | 3.14 |
| Enjoyment of life | 131 | 19.47 | 14 | 37.84** | 3.03** | 1.37 | 6.69 |
= p<.05;
=p<.01;
OR= odds ratio; N= number of patients with moderate/severe symptoms; LCI= Lower 95% Confidence Interval; UCI= Upper 95% Confidence Interval. Each symptom is coded as moderate /severe =1, no/mild =0; OR is for comparison between younger and older patients, after adjusting for other covariates. OR >1 indicates younger patients have higher odds of having moderate/severe symptom than older patients. Covariates include: race, ethnicity, disease status, advanced disease, performance status, weight loss in the previous 6 months, prior systemic or radiotherapy, currently receiving therapy, counseling service, participating in support group, number of current medications, years since cancer diagnosis and gender.