Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Representative reductive amination handle installation conditions
| means of handle attachment | reducing agent | solvent and conditions | rxn time | yield | ref |
|---|---|---|---|---|---|
| aldehyde | NaCNBH3 | HOAc, r.t. | 1 h | 80% | 11 |
| aldehyde | BH3-Et3N | HCl/EtOH, 0°C | 5 m | 65% | 16 |
| ketone | BH3- tBuNH2 | HCl,/EtOH/ dioxane, 0 °C | 2.5 h | 69% | 19 |
| ketone | NaCNBH3 | HOAc/DCE/ MeOH, r.t. | 90 m | 88% | 24 |
| glycyl linker | BH3-Me3N | HCl/EtOH, 0 °C | 5 h | 85% | 15 |
