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. 1978 Jan;75(1):294–297. doi: 10.1073/pnas.75.1.294

Mutant RNA polymerase of Escherichia coli terminates transcription in strains making defective rho factor.

L P Guarente, J Beckwith
PMCID: PMC411233  PMID: 343107

Abstract

We have isolated a rifampicin-resistant mutant of Escherichia coli RNA polymerase that restores transcription termination in strains with a defective rho protein. In such strains, the mutant RNA polymerase terminates transcription at normally rho-dependent sites at the end of the trp operon, in bacteriophage lambda, and within the lac operon. In addition, a strain with this mutant RNA polymerase remains viable with an amber mutation in rho, whereas a strain with wild-type RNA polymerase does not. These results suggest that the mutant RNA polymerase can terminate transcription at normally rho-dependent sites in the absence of rho.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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