Figure 8.
Protective effects of 3-benzyl-6-chloro-2-pyrone (3-BCP) on biomarkers of fatty acid ethyl ester-induced acute pancreatitis (FAEE-AP) induced by palmitoleic acid (POA)/ethanol. FAEE-AP was induced by two intraperitoneal injections of ethanol (1.35 g/kg) and POA (150 mg/kg). The effects of inhibition of oxidative metabolism of ethanol (OME) with 4-methylpyrazole (4-MP; 10 mg/kg) or non-OME with 3-BCP (30 mg/kg), given on the first injection of POA/ethanol, were assessed on (A) Serum amylase, (B) Pancreatic trypsin activity, (C) Pancreatic myeloperoxidase activity (normalised) and (D) Serum interleukin-6 (IL-6). Control mice received saline injections only. Mice were sacrificed 24 h after the first injection. *p<0.05 compared to both saline and POA controls, #p<0.05 compared to the POA/ethanol group. Values are mean±SE of 6 mice.