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. Author manuscript; available in PMC: 2014 Jul 28.
Published in final edited form as: Circulation. 2012 Aug 24;126(15):1907–1916. doi: 10.1161/CIRCULATIONAHA.112.106245

Figure 1.

Figure 1

A) BMPR2 splice isoforms. Shaded areas indicate exons and open boxes untranslated regions. Exon 12 is the largest exon of BMPR2 and its length is indicated by the number on top. Isoform-A is the full length BMPR2 mRNA while isoform-B is lacks exon 12 and is the minor BMPR2 isoform. B) Isoform A and B mRNA levels in pooled mRNA isolated from various body tissues including PMVECs as determined by relative real-time PCR. PMVEC were included in this analysis as they are an important cell in PAH pathogenesis.