Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1978 Feb;75(2):847–851. doi: 10.1073/pnas.75.2.847

Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.

D Gospodarowicz, K K Thakral
PMCID: PMC411354  PMID: 273247

Abstract

Factors controlling the changes in the vascular pattern of the ovary that occur during the reproductive cycle have been investigated. By using the rabbit cornea, the abilities of ovarian corpus luteum and of follicles to induce neovascularization have been compared. While the corpus luteum is capable of inducing neovascularization, the follicles do not have this ability. It is therefore likely that the corpus luteum actively participates in its own neovascularization by secreting a factor that we have called "corpus leutem angiogenic factor" (CLAF).

Full text

PDF
847

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHTON N., WARD B., SERPELL G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol. 1954 Jul;38(7):397–432. doi: 10.1136/bjo.38.7.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Auerbach R., Kubai L., Sidky Y. Angiogenesis induction by tumors, embryonic tissues, and lymphocytes. Cancer Res. 1976 Sep;36(9 Pt 2):3435–3440. [PubMed] [Google Scholar]
  3. Ausprunk D. H., Knighton D. R., Folkman J. Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. Am J Pathol. 1975 Jun;79(3):597–618. [PMC free article] [PubMed] [Google Scholar]
  4. Ellsworth L. R., Armstrong D. T. Inhibition of luteinization of transplanted rat ovarian follicles by polyphloretin phosphate. Endocrinology. 1974 Mar;94(3):892–896. doi: 10.1210/endo-94-3-892. [DOI] [PubMed] [Google Scholar]
  5. Folkman J., Merler E., Abernathy C., Williams G. Isolation of a tumor factor responsible for angiogenesis. J Exp Med. 1971 Feb 1;133(2):275–288. doi: 10.1084/jem.133.2.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fromer C. H., Klintworth G. K. An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. Am J Pathol. 1975 Jun;79(3):537–554. [PMC free article] [PubMed] [Google Scholar]
  7. GOSPODAROWICZ D. THE ACTION OF FOLLICLE STIMULATING HORMONE AND OF HUMAN CHORIONIC GONADOTROPHIN UPON STEROID SYNTHESIS BY RABBIT OVARIAN TISSUES IN VITRO. Acta Endocrinol (Copenh) 1964 Oct;47:293–305. doi: 10.1530/acta.0.0470293. [DOI] [PubMed] [Google Scholar]
  8. GOSPODAROWICZ D. THE IN VITRO PRODUCTION OF ANDROGENS BY FOLLICULAR TISSUE OF RABBITS. Acta Endocrinol (Copenh) 1964 Oct;47:306–313. doi: 10.1530/acta.0.0470306. [DOI] [PubMed] [Google Scholar]
  9. Gimbrone M. A., Jr, Cotran R. S., Leapman S. B., Folkman J. Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst. 1974 Feb;52(2):413–427. doi: 10.1093/jnci/52.2.413. [DOI] [PubMed] [Google Scholar]
  10. Gospodarowicz D. Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature. 1974 May 10;249(453):123–127. doi: 10.1038/249123a0. [DOI] [PubMed] [Google Scholar]
  11. Gospodarowicz D., Moran J. S., Braun D. L. Control of proliferation of bovine vascular endothelial cells. J Cell Physiol. 1977 Jun;91(3):377–385. doi: 10.1002/jcp.1040910307. [DOI] [PubMed] [Google Scholar]
  12. Gospodarowicz D., Moran J., Braun D., Birdwell C. Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4120–4124. doi: 10.1073/pnas.73.11.4120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gospodarowicz D. Preparation and characterization of plasma membranes from bovine corpus luteum. J Biol Chem. 1973 Jul 25;248(14):5050–5056. [PubMed] [Google Scholar]
  14. Gospodarowicz D. Purification of a fibroblast growth factor from bovine pituitary. J Biol Chem. 1975 Apr 10;250(7):2515–2520. [PubMed] [Google Scholar]
  15. Greenblatt M., Shubi P. Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique. J Natl Cancer Inst. 1968 Jul;41(1):111–124. [PubMed] [Google Scholar]
  16. HARRIS G. W. SEX HORMONES, BRAIN DEVELOPMENT AND BRAIN FUNCTION. Endocrinology. 1964 Oct;75:627–648. doi: 10.1210/endo-75-4-627. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES