Abstract
A genetic mapping procedure, called the duplication-deficiency method, is described. This method permits the genetic location of a translocation to be determined within a linkage group without the use of recombination. By utilizing the duplication-deficiency method to define the genetic breakpoints for a series of translocations involving a given chromosome and integrating this information with their cytological breakpoints, obtained by Giemsa banding, a genetic map of the chromosomes is constructed whereby groups of loci are assigned to banded regions. Duplication-deficiency mapping and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)145H translocations together with information from the c25H deletion have permitted mouse chromosome 7 to be divided into six and chromosome 19 into two definable genetic regions.
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Selected References
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- Burgerhout W. G., Jongsma A. P., de Wit J., van Someren H., Meera Khan P. Regional mapping of seven enzyme loci on human chromosome 1 by use of somatic cell hybridization. Birth Defects Orig Artic Ser. 1975;11(3):90–92. [PubMed] [Google Scholar]
- CATTANACH B. M. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl. 1961;92:165–182. doi: 10.1007/BF00890283. [DOI] [PubMed] [Google Scholar]
- Cattanach B. M. The location of Cattanach's translocation in the X-chromosome linkage map of the mouse. Genet Res. 1966 Oct;8(2):253–256. doi: 10.1017/s0016672300010107. [DOI] [PubMed] [Google Scholar]
- Eicher E. M., Green M. C. The T6 translocation in the mouse: its use in trisomy mapping, centromere localization, and cytological identification of linkage group 3. Genetics. 1972 Aug;71(4):621–632. doi: 10.1093/genetics/71.4.621. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eicher E. M. The Position of ru-2 and qv with Respect to the FLECKED Translocation in the Mouse. Genetics. 1970 Mar;64(3-4):495–510. doi: 10.1093/genetics/64.3-4.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eicher E. M. The genetic extent of the insertion involved in the flecked translocation in the mouse. Genetics. 1967 Feb;55(2):203–212. doi: 10.1093/genetics/55.2.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eicher E. M. The identification of the chromosome bearing linkage group XII in the mouse. Genetics. 1971 Oct;69(2):267–271. doi: 10.1093/genetics/69.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eicher E. M. Translocation trisomic mice: production by female but not male translocation carriers. Science. 1973 Apr 6;180(4081):81–81. doi: 10.1126/science.180.4081.81. [DOI] [PubMed] [Google Scholar]
- Eicher E. M. X-autosome translocations in the mouse: total inactivation versus partial inactivation of the X chromosome. Adv Genet. 1970;15:175–259. [PubMed] [Google Scholar]
- Erickson R. P., Eicher E. M., Gluecksohn-Waelsch S. Demonstration in mouse of X-ray induced deletions for a know enzyme structural locus. Nature. 1974 Mar 29;248(447):416–418. doi: 10.1038/248416a0. [DOI] [PubMed] [Google Scholar]
- Francke U., Nesbitt M. Cattanach's translocation: cytological characterization by quinacrine mustard staining. Proc Natl Acad Sci U S A. 1971 Dec;68(12):2918–2920. doi: 10.1073/pnas.68.12.2918. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson A. S., Eicher E. M., Yu M. T., Atwood K. C. The chromosomal location of ribosomal DNA in the mouse. Chromosoma. 1974;49(2):155–160. doi: 10.1007/BF00348887. [DOI] [PubMed] [Google Scholar]
- Henderson A. S., Warburton D., Atwood K. C. Location of ribosomal DNA in the human chromosome complement. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3394–3398. doi: 10.1073/pnas.69.11.3394. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones K. W. Chromosomal and nuclear location of mouse satellite DNA in individual cells. Nature. 1970 Mar 7;225(5236):912–915. doi: 10.1038/225912a0. [DOI] [PubMed] [Google Scholar]
- Jones K. W., Prosser J., Corneo G., Ginelli E. The chromosomal location of human satellite DNA 3. Chromosoma. 1973 Jul 18;42(4):445–451. doi: 10.1007/BF00399411. [DOI] [PubMed] [Google Scholar]
- Jones K. W., Purdom I. F., Prosser J., Corneo G. The chromosomal localisation of human satellite DNA I. Chromosoma. 1974;49(2):161–171. doi: 10.1007/BF00348888. [DOI] [PubMed] [Google Scholar]
- Kouri R. E., Miller D. A., Miller O. J., Dev V. G., Grewal M. S., Hutton J. J. Identification by quinacrine fluorescence of the chromosome carrying mouse linkage group I in the Cattanach translocation. Genetics. 1971 Sep;69(1):129–132. doi: 10.1093/genetics/69.1.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lane P. W., Eicher E. M., Southard J. L. Chromosome 19 of the house mouse. J Hered. 1974 Sep-Oct;65(5):297–300. doi: 10.1093/oxfordjournals.jhered.a108532. [DOI] [PubMed] [Google Scholar]
- Lyon M. F., Meredith R. Autosomal translocations causing male sterility and viable aneuploidy in the mouse. Cytogenetics. 1966;5(5):335–354. doi: 10.1159/000129909. [DOI] [PubMed] [Google Scholar]
- Miller D. A., Dev V. G., Tantravahi R., Miller O. J., Schiffman M. B., Yates R. A., Gluecksohn-Waelsch S. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics. 1974 Nov;78(3):905–910. doi: 10.1093/genetics/78.3.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller O. J., Miller D. A., Kouri R. E., Dev V. G., Grewal M. S., Hutton J. J. Assignment of linkage groups 8 and X to chromosomes in Mus musculus and identification of the centromeric end of linkage group I. Cytogenetics. 1971;10(6):452–464. doi: 10.1159/000130165. [DOI] [PubMed] [Google Scholar]
- Nesbitt M. N., Francke U. A system of nomenclature for band patterns of mouse chromosomes. Chromosoma. 1973;41(2):145–158. doi: 10.1007/BF00319691. [DOI] [PubMed] [Google Scholar]
- Pardue M. L., Gall J. G. Chromosomal localization of mouse satellite DNA. Science. 1970 Jun 12;168(3937):1356–1358. doi: 10.1126/science.168.3937.1356. [DOI] [PubMed] [Google Scholar]
- Searle A. G., Ford C. E., Beechey C. V. Meiotic disjunction in mouse translocations and the determination of centromere position. Genet Res. 1971 Oct;18(2):215–235. doi: 10.1017/s0016672300012611. [DOI] [PubMed] [Google Scholar]
- Triman K. L., Davisson M. T., Roderick T. H. A method for preparing chromosomes from peripheral blood in the mouse. Cytogenet Cell Genet. 1975;15(3):166–176. doi: 10.1159/000130515. [DOI] [PubMed] [Google Scholar]
- Wolfe H. G. Mapping the hemoglobin locus in mice transmitting the flecked translocation. Genetics. 1967 Feb;55(2):213–218. doi: 10.1093/genetics/55.2.213. [DOI] [PMC free article] [PubMed] [Google Scholar]