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. 1978 Mar;75(3):1466–1469. doi: 10.1073/pnas.75.3.1466

Analysis of malignancy in human cells: malignant and transformed phenotypes are under separate genetic control.

E J Stanbridge, J Wilkinson
PMCID: PMC411493  PMID: 274733

Abstract

Human cell hybrids derived from malignant HeLa and normal fibroblast parental cells expressed many of the transformed properties of the HeLa parent but their tumor-producing capability was suppressed. Hybrids derived from HeLa/HeLa fusions retained both their transformed and malignant phenotypes. Thus, an apparent separation of the control of the transformed versus malignant phenotype is indicated. Furthermore, several transformed properties--including lack of density-dependent inhibition of growth, lectin agglutination, lowered requirement for serum growth factors, and anchorage independence--are expressed coordinately in the nontumorigenic hybrids. This finding suggests that none of these properties by themselves, or in concert, endows a cell with tumorigenic potential.

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Selected References

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