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. 1978 Mar;75(3):1596–1599. doi: 10.1073/pnas.75.3.1596

Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.

E X Albuquerque, P W Gage
PMCID: PMC411521  PMID: 206910

Abstract

Perhydrohistrionicotoxin, at concentrations of 10(-12)-10(-7) M, depressed the current generated by iontophoretic application of acetylcholine to endplate regions of soleus and extensor digitorum longus muscles of rats. However, no changes in the amplitude or time course of spontaneous miniature endplate potentials or currents were seen with these concentrations of toxin. Evoked endplate currents were also unaffected by the toxin. Similarly, the responses to iontophoretic acetylcholine were depressed by these concentrations of perhydrohistrionicotoxin in chronically denervated muscles. Depression of responses in both normal and chronically denervated muscles developed gradually, was greater at higher concentrations, and was reversible. The different effects of the toxin on neurally evoked currents and currents produced by iontophoretic application of acetylcholine raise the possibility of the existence of two different population of receptor complexes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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