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. 1978 Mar;75(3):1600–1604. doi: 10.1073/pnas.75.3.1600

Protein deficiency and energy restriction in young cebus monkeys.

K W Samonds, D M Hegsted
PMCID: PMC411522  PMID: 418417

Abstract

Infant cebus monkeys (Cebus albifrons) were fed liquid formulas that were limited in protein, energy, or a combination of the two restrictions. Weight gain, food intake, hematological development, and plasma protein and cholesterol levels were monitored over a 20-week period. The animals restricted in protein developed the classical signs of protein deficiency--reductions in plasma albumin, a mild anemia, accumulation of fat in the liver, and, in a few cases, facial edema. These animals maintained a relatively high energy intake, and apparently wasted energy when compared to similarly non-growing energy-restricted animals. Energy-restricted animals did not exhibit these symptoms, even when their daily protein intake was reduced to match that of protein-restricted monkeys. It is concluded that an energy restriction superimposed upon a limited protein intake did not increase protein requirements or precipitate protein deficiency.

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Selected References

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  1. Ausman L. M., Hayes K. C., Lage A., Hegsted D. M. Nursery care and growth of Old and New World infant monkeys. Lab Anim Care. 1970 Oct;20(5):907–913. [PubMed] [Google Scholar]
  2. CARPENTER K. J., GOTSIS A., HEGSTED D. M. Estimation of total cholesterol in serum by a micro method. Clin Chem. 1957 Aug;3(4 Pt 1):233–238. [PubMed] [Google Scholar]
  3. Calloway D. H., Margen S. Variation in endogenous nitrogen excretion and dietary nitrogen utilization as determinants of human protein requirement. J Nutr. 1971 Feb;101(2):205–216. doi: 10.1093/jn/101.2.205. [DOI] [PubMed] [Google Scholar]
  4. Fleagle J. G., Samonds K. W., Hegsted D. M. Physical growth of cebus monkeys, Cebus albifrons, during protein or calorie deficiency. Am J Clin Nutr. 1975 Mar;28(3):246–253. doi: 10.1093/ajcn/28.3.246. [DOI] [PubMed] [Google Scholar]
  5. Garza C., Scrimshaw N. S., Young V. R. Human protein requirements: the effect of variations in energy intake within the maintenance range. Am J Clin Nutr. 1976 Mar;29(3):280–287. doi: 10.1093/ajcn/29.3.280. [DOI] [PubMed] [Google Scholar]
  6. Gopalan C., Swaninathan M. C., Kumari V. K., Rao D. H., Vijayaraghavan K. Effect of calorie supplementation on growth of undernourished children. Am J Clin Nutr. 1973 May;26(5):563–566. doi: 10.1093/ajcn/26.5.563. [DOI] [PubMed] [Google Scholar]
  7. HOLT L. E., Jr, SNYDERMAN S. E., NORTON P. M., ROITMAN E., FINCH J. THE PLASMA AMINOGRAM IN KWASHIORKOR. Lancet. 1963 Dec 28;2(7322):1342–1348. [PubMed] [Google Scholar]
  8. Kasper H., Thiel H., Ehl M. Response of body weight to a low carbohydrate, high fat diet in normal and obese subjects. Am J Clin Nutr. 1973 Feb;26(2):197–204. doi: 10.1093/ajcn/26.2.197. [DOI] [PubMed] [Google Scholar]
  9. Miller D. S., Parsonage S. Resistance to slimming: adaptation or illusion? Lancet. 1975 Apr 5;1(7910):773–775. doi: 10.1016/s0140-6736(75)92437-x. [DOI] [PubMed] [Google Scholar]
  10. Rao K. S. Evolution of kwashiorkor and marasmus. Lancet. 1974 Apr 20;1(7860):709–711. doi: 10.1016/s0140-6736(74)92908-0. [DOI] [PubMed] [Google Scholar]
  11. Samonds K. W., Ausman L. M., Hegsted D. M. Hematological development of the cebus monkey (Cebus albifrons and apella). Folia Primatol (Basel) 1974;22(1):72–79. doi: 10.1159/000155618. [DOI] [PubMed] [Google Scholar]
  12. Thurm D. A., Samonds K. W., Hegsted D. M. The effects of a 20-week nutritional insult on the skeletal development of Cebus albifrons during the 1st year of life. Am J Clin Nutr. 1976 Jun;29(6):621–625. doi: 10.1093/ajcn/29.6.621. [DOI] [PubMed] [Google Scholar]

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