Table 1.

Identifying Likely Pathologic Variants in Malignant Hyperthermia Families

Filter	Family A	Family B	Family C	Subject G
Not homozygous reference	15,259	16,477	15,344	22,973
Missense/Nonsense/Splice Site/Indel	6,499	6,998	6,538	9,220
Not in databases	139	208	132	347
Not in control exomes	7	23	2	103
RYR1 or CACNA1S variants	1	1	1	1

The numbers in each column represent counts of individual exome variants among affected members in each family. The first row indicates the number of variants in each family that were high quality (>7x coverage), shared by affected members, and were different from the reference genome. In the lower rows, each cell lists the number of variants that remain after applying the indicated filter.

calcium channel, voltage-dependent, L type, α1S subunit gene = CACNA1S; insertion or deletion = indel; ryanodine receptor 1 gene =RYR1.