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. 1979 Sep;76(9):4395–4399. doi: 10.1073/pnas.76.9.4395

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

H T Orr, J A Lopez de Castro, P Parham, H L Ploegh, J L Strominger
PMCID: PMC411581  PMID: 92029

Abstract

The complete amino acid sequence for papain-solubilized HLA-B7 heavy chain is compared with the partial sequences of HLA-A2 and H-2Kb heavy chains. Although these molecules are highly conserved (i.e., 80% homology in comparing HLA-B7 with HLA-A2; 72% and 74% homology in comparing H-2Kb with HLA-A2 and HLA-B7, respectively), two stretches of greater variability are observed. These clusters of variability are discussed in terms of their possible involvement in the alloantigenic determinant(s) characteristic of these highly polymorphic membrane antigens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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