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. 1979 Sep;76(9):4683–4686. doi: 10.1073/pnas.76.9.4683

Selective loss of noradrenergic phenotypic characters in neuroblasts of the rat embryo.

G M Jonakait, J Wolf, P Cochard, M Goldstein, I B Black
PMCID: PMC411645  PMID: 41248

Abstract

To define the fate of embryonic neuroblasts in rat gut, which transiently express several noradrenergic traits, we investigated the high-affinity uptake of norepinephrine. At 12.5 days of gestation, these cells exhibited immunoreactivity to tyrosine hydroxylase [tyrosine 3-monoxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] and endogenous catecholamine fluorescence. However, by 13.5 days these noradrenergic neurotransmitter phenotypic characters essentially disappeared. In contrast, norepinephrine uptake, which was also apparent at 12.5 days, persisted at least through 17.5 days. These observations indicate that norepinephrine uptake develops as an additional noradrenergic characteristic in these cells and persists after the disappearance of other noradrenergic traits. Consequently, neurotransmitter phenotypic characters may be transiently displayed during normal development in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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