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. 1979 Nov;76(11):5858–5862. doi: 10.1073/pnas.76.11.5858

Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors.

T Ishizaka, J C Foreman, A R Sterk, K Ishizaka
PMCID: PMC411751  PMID: 93285

Abstract

Rabbit antibody against IgE receptors or its F(ab')2 fragments induced an increase of 45Ca uptake into normal mast cells, and this process was accompanied by histamine release. Evidence was obtained that a substantial portion of 45Ca uptake was due to movement of calcium across the cell membrane. Neither 45Ca uptake nor histamine release was induced by Fab' monomer fragments of the antireceptor antibody. However, bridging of receptor-bound Fab' fragments by antirabbit IgG or bridging of receptor-bound IgE by anti-IgE induced an increase in 45Ca uptake. The results collectively indicate that crosslinking IgE receptors increases the membrane permeability of the mast cells toward calcium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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