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. 1979 Nov;76(11):5934–5938. doi: 10.1073/pnas.76.11.5934

Changes in plasma lipoprotein distribution and formation of two unusual particles after heparin-induced lipolysis in hypertriglyceridemic subjects.

T M Forte, R M Krauss, F T Lindgren, A V Nichols
PMCID: PMC411767  PMID: 230493

Abstract

Lipoprotein morphology and distribution were studied in three moderately to severely hypertriglyceridemic patients after heparin-induced lipolysis. Lipoproteins with a flotation rate of Sf degrees 12-20 in rho 1.063-g/ml NaCl solution increased substantially in mass 2.5-10 min after heparin administration. This fraction contained 40- to 120-nm flattened particles and increased concentrations of phospholipid and free cholesterol. At 2.5 and 10 min after heparin, the high density lipoproteins (HDL) of rho, 1.126-1.21 g/ml contained small (5.8-nm diameter) spherical particles. Both types of particles disappeared 30-60 min after heparin. Results indicated that with lipolysis HDL3 may be transformed into HDL2a by incorporation of chylomicron and very low density lipoprotein constituents. It is suggested that the 40- to 120-nm particles represent surface fragments of chylomicrons and very low density lipoproteins generated during lipolysis, whereas the 5.8-nm particles are produced either by fragmentation of the large surface constituents or by loss of lipid from existing HDL3.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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